{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:25:07Z","timestamp":1770279907743,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG SFB1160\/2 TPA01"],"award-info":[{"award-number":["DFG SFB1160\/2 TPA01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Z01"],"award-info":[{"award-number":["Z01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This report offers novel clinical and diagnostic aspects of the association between germline mutations in <jats:italic>HAVCR2<\/jats:italic> and subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL). The patient presented with panniculitis\u2010like T\u2010cell lymphoma involving mesenteric fatty tissue associated with hemophagocytic lymphohistiocytosis (HLH). Five years later, he developed a clonally unrelated SPTCL and underwent hematopoietic stem cell transplantation. Retrospectively, he was found to carry germline mutations in <jats:italic>HAVCR2<\/jats:italic> associated with reduced T\u2010cell immunoglobulin mucin\u20103 (TIM\u20103) expression. We show that mesenteric fatty tissue localization of SPTCL can be the presenting manifestation of TIM\u20103 deficiency, that this condition predisposes to recurrent lymphoma, and that flow cytometry is a possible screening tool.<\/jats:p>","DOI":"10.1002\/pbc.28302","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T12:27:56Z","timestamp":1586867276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["TIM\u20103 deficiency presenting with two clonally unrelated episodes of mesenteric and subcutaneous panniculitis\u2010like T\u2010cell lymphoma and hemophagocytic lymphohistiocytosis"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-0761","authenticated-orcid":false,"given":"Oliver","family":"Wegehaupt","sequence":"first","affiliation":[{"name":"Center for Pediatrics and Adolescent Medicine Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Institute for Immunodeficiency Center for Chronic Immunodeficiency (CCI) Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency Center for Chronic Immunodeficiency (CCI) Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Faculty of Biology University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Wehr","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency (CCI) Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Department of Medicine I Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Medicine I Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Schmitt\u2010Graeff","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency (CCI), Medical Center University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Radiology St. Josef's Hospital  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine University of Ulm  Ulm Germany"},{"name":"Institute for Transfusion Medicine and Immunogenetics Ulm German Red Cross Blood Service Baden\u2010Wuerttemberg\u2013Hessen  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kratz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Center for Pediatrics and Adolescent Medicine Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Ehl","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency Center for Chronic Immunodeficiency (CCI) Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20502"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12520"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0251-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028340"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0854-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12436"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12452"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24462"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2543"}],"container-title":["Pediatric Blood &amp; 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