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Individuals with CMMRD are affected with multiple tumors arising from multiple organs during childhood, and these individuals rarely reach adulthood without specific interventions. The most common tumors observed are central nervous system, hematological, and gastrointestinal malignancies. The incidence of CMMRD is expected to be high in low\u2010resource settings due to a high rate of consanguinity in these regions, and it is thought to be underrecognized and consequently underdiagnosed. This position paper is therefore important to provide a summary of the current situation, and to highlight the necessity of increasing awareness, diagnostic criteria, and surveillance to improve survival for patients and family members.<\/jats:p>","DOI":"10.1002\/pbc.28309","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T10:59:13Z","timestamp":1590836353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Position paper: Challenges and specific strategies for constitutional mismatch repair deficiency syndrome in low\u2010resource settings"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-8174","authenticated-orcid":false,"given":"Rejin","family":"Kebudi","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Oncology Institute Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-5885","authenticated-orcid":false,"given":"Nisreen","family":"Amayiri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King Hussein Cancer Center Hematology\/Oncology  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Abedalthagafi","sequence":"additional","affiliation":[{"name":"Genomics Research Department Saudi Human Genome Project King Fahad Medical City King Abdulaziz City for Science and Technology  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"As\u0131m Noor","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Dubai Hospital  Dubai UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Kirmani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics &amp; Child Health Aga Khan University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naureen","family":"Musthaq","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences M.M. 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