{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:31:52Z","timestamp":1790757112678,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of our study is to evaluate the role of <jats:sup>18<\/jats:sup>F\u2010labeled fluorodeoxy glucose positron emission tomography (<jats:sup>18<\/jats:sup>FDG\u2010PET) scan for the detection of viable residual mass in pediatric mature B\u2010cell non\u2010Hodgkin lymphoma (NHL). This study also aims to detect the negative predictive value, positive predictive value (PPV), sensitivity, and specificity of <jats:sup>18<\/jats:sup>FDG\u2010PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A retrospective, cross\u2010sectional nonrandomized study was carried out. We included all patients with newly diagnosed mature B\u2010cell NHL treated at the Children Cancer Hospital Egypt during the period between July 2007 and the end of May 2018. Patients were included in the study if they (a) had a residual tumor mass, (b) underwent an <jats:sup>18<\/jats:sup>FDG\u2010PET scan, and (c) had a pathologic documentation of this residual tumor. Patients were followed up till June 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients were included, for whom 39 biopsies were performed. Mean age was 7.7 years. Median follow\u2010up period was 52.8, range 6.1 to 117 months.<jats:sup>18<\/jats:sup>FDG\u2010PET scan was positive (Deauville score 3, 4, or 5) in 24 of 39 patients (61.5%), while it was negative (Deauville score 1 or 2) in 15 patients (38.5%). Positive <jats:sup>18<\/jats:sup>FDG\u2010PET scan and biopsy were performed in 15 of 39 samples (38.4%; true positive, TP), while they were both negative in 13 samples (33.3%; true negative). Nine patients (23%) had positive scan and a negative biopsy (false positive), while 2 patients had negative uptake and a positive biopsy (false negative, FN)). Sensitivity of the <jats:sup>18<\/jats:sup>FDG\u2010PET scan was 88.2% and specificity was 59.1%. PPV was 62.5% and NPPV was 86.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changing therapy on the basis of a positive finding alone at the time of evaluation is not recommended. FN results exist, so biopsy confirmation is required to avoid the missing refractory disease. If negative, <jats:sup>18<\/jats:sup>FDG<jats:sup>\u2010<\/jats:sup>PET can replace a biopsy if the latter is inaccessible or carries an unnecessary risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28310","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T17:18:24Z","timestamp":1594142304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Can FDG\u2010PET replace biopsy for the evaluation of residual tumor in pediatric mature B\u2010cell non\u2010Hodgkin lymphoma?"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-8596","authenticated-orcid":false,"given":"Hany Abdel","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Institute Cairo University and Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah Fathy","family":"El Semary","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Faculty of Medicine Beni Suef University and Children Cancer Hospital Egypt  Beni Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Surgery Helwan University, and Children Cancer Hospital Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa El","family":"Kenaai","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Institute Cairo University, and Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Cancer Institute Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Zaky","sequence":"additional","affiliation":[{"name":"Department of Radio\u2010diagnosis National Cancer Institute Cairo University and Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28745"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318238f72b"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13219"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036665"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036673"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1741-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2014.00054"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e328334fc14"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/11.suppl_1.S147"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-359943"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872517"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601179783"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-3-71"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.07.035"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3181a34552"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.1.g99ja0761"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-010-0062-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110936"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.4.1761019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.251045045"},{"issue":"11","key":"e_1_2_10_23_1","first-page":"1789","article-title":"Patterns of (18)F\u2010FDG uptake in adipose tissue and muscle: a potential source of false\u2010positives for PET","volume":"44","author":"Yeung HW","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.4.1831127"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.271065080"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3703"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2006.7.1.57"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2017.10.012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.121434"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.0745"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.28310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28310","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:45:19Z","timestamp":1693892719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/pbc.28310"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28310","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"2019-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28310"}}