{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T07:55:45Z","timestamp":1782028545906,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rearrangements of chromosome 8q24\/<jats:italic>MYC<\/jats:italic> (8q24\/<jats:italic>MYC<\/jats:italic>\u2010r), resulting from t(8;14)(q24;q32), t(2;8)(p11;q24), or t(8;22)(q24;q11), are mainly associated with Burkitt lymphoma\/leukemia (BL) and rarely observed in patients with B\u2010cell precursor acute lymphoblastic leukemia (BCP\u2010ALL). The characteristics of BCP\u2010ALL with 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A retrospective nationwide study of data from patients with pediatric BCP\u2010ALL with 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r in Japan was conducted to clarify the clinical and biological characteristics associated with 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r BCP\u2010ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients with BCP\u2010ALL with 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r, including three with double\u2010hit leukemia (DHL) (two with t(8;14)(q24;q32) and t(14;18)(q32;q21) and one with t(8;14) and t(3;22)(q27;q11)), were identified. Patients with BCP\u2010ALL with 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r had higher median age and uric acid and lactate dehydrogenase levels, than those without 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r. All patients were initially treated with ALL\u2010type chemotherapy; however, four, including one with DHL, were switched to BL\u2010type chemotherapy, based on cytogenetic findings. One patient relapsed after standard\u2010risk ALL\u2010type chemotherapy, and two patients with DHL did not attain complete remission with chemotherapy; all three died within 11 months. The other seven patients treated with BL\u2010type or high\u2010risk ALL\u2010type chemotherapy are alive without disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical and laboratory features of BL with IG\u2010<jats:italic>MYC<\/jats:italic> rearrangement, displaying a BCP immunophenotype (Wagener et\u00a0al. and Herbrueggen et\u00a0al. termed it as pre\u2010BLL), are similar to those of BCP\u2010ALL with 8q24\/<jats:italic>MYC<\/jats:italic>\u2010r. Low\u2010risk ALL\u2010type chemotherapy may not be appropriate for them, and further studies are required to establish an adequate therapeutic strategy. Further studies of DHL to identify new treatment strategies are also needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28341","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T11:55:08Z","timestamp":1587642908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nationwide study of pediatric B\u2010cell precursor acute lymphoblastic leukemia with chromosome 8q24\/<i>MYC<\/i> rearrangement in Japan"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3665-401X","authenticated-orcid":false,"given":"Kimiyoshi","family":"Sakaguchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hamamatsu University School of Medicine  Hamamatsu Japan"},{"name":"Clinical Research Center National Hospital Organization Nagoya Medical Center  Nagoya 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