{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:24:06Z","timestamp":1774052646862,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acinic cell carcinoma (AciCC) is rare in children; therefore, reaching a consensus on its management is challenging and radiotherapy is limited by concerns about long\u2010term toxicity. The purpose of this study is to analyze the effectiveness and safety of surgery plus postoperative <jats:sup>125<\/jats:sup>I interstitial brachytherapy (IBT) for children and adolescents with AciCC of the parotid gland (PG) treated at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Sixteen patients \u2264 18 years old with AciCC of the PG treated with surgery plus <jats:sup>125<\/jats:sup>I IBT from 2007 to 2018 were included. Surgery was the primary treatment; ten patients underwent total gross excision and six subtotal gross excision. The matched peripheral dose was 60\u2010120\u00a0Gy. Overall survival, disease\u2010free survival (DFS), local control rate, distant metastasis, and radiation\u2010associated toxicities were analyzed, and factors influencing outcomes were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During follow\u2010up (1.8\u201012.6 years; mean, 6.3 years), lymph node metastasis was observed in one case, 2.6 years after <jats:sup>125<\/jats:sup>I IBT treatment. The five\u2010year overall and DFS rates were 100% and 91.7%, respectively. On univariate analysis, tumor size \u2265 3\u00a0cm (100%\u00a0vs 50%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) and extraglandular extension (100%\u00a0vs 50%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) were significant prognostic indicators for DFS. No severe radiation\u2010associated complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children and adolescents with AciCC of the PG with high\u2010risk features can be managed using surgery plus postoperative <jats:sup>125<\/jats:sup>I IBT with excellent local control. Radiation\u2010related complications were minor. Patients with facial nerve involvement can have their facial nerves preserved. Residual tumors can be safely managed using adjuvant <jats:sup>125<\/jats:sup>I IBT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28343","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T12:40:48Z","timestamp":1589200848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of surgery combined with postoperative <sup>125<\/sup>I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents"],"prefix":"10.1002","volume":"67","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing P. R. 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