{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:50:29Z","timestamp":1790387429731,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","award":["Filling the Gap career development program"],"award-info":[{"award-number":["Filling the Gap career development program"]}],"id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"Abstract<\/jats:title>\n \n Here, we present a patient with high\u2010grade neuroepithelial tumors with mutations in the BCL6 corepressor\n BCOR<\/jats:italic>\n (HGNET\u2010BCOR), a rare, highly malignant brain tumor with poor prognosis. The patient underwent gross total tumor resection (GTR), high\u2010dose chemotherapy, and, after local relapse, GTR, proton radiation, and chemotherapy. After a 7.5\u00a0year\u2010long complete remission, the tumor recurred locally, was treated by GTR, and responded to temozolomide treatment. In addition to an internal tandem duplication in\n BCOR<\/jats:italic>\n common to the majority of HGNET\u2010BCOR cases, molecular analysis revealed a second\n BCOR<\/jats:italic>\n mutation in this tumor: a frame shift mutation. The combination of these mutations was associated with relatively low\n BCOR<\/jats:italic>\n expression compared to other HGNET\u2010BCOR cases.\n <\/jats:p>","DOI":"10.1002\/pbc.28384","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T09:07:29Z","timestamp":1588928849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A single supratentorial high\u2010grade neuroepithelial tumor with two distinct\n BCOR<\/i>\n mutations, exceptionally long complete remission and survival"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-9425","authenticated-orcid":false,"given":"Juliane","family":"Bremer","sequence":"first","affiliation":[{"name":"Institute of Neuropathology University Hospital Zurich Zurich Switzerland"},{"name":"Institute of Neuropathology University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Kottke","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal D.","family":"Johann","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center (KiTZ) Heidelberg Germany"},{"name":"Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany"},{"name":"Department of Pediatric Hematology and Oncology University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"von Hoff","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Brazzola","sequence":"additional","affiliation":[{"name":"Istituto Pediatrico della Svizzera Italiana Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Grotzer","sequence":"additional","affiliation":[{"name":"Department of Oncology University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kool","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center (KiTZ) Heidelberg Germany"},{"name":"Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Rushing","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas U.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Oncology University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12747"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos292"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23174"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13092"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000866"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12585"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.05.158"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2019.19.02.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP301162"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9891"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170167"}],"container-title":["Pediatric 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