{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:33:44Z","timestamp":1789576424913,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010637","name":"Huntsman Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, we aimed to evaluate incidence rates and family risk of the most common childhood cancers, tumors in the central nervous system (CNS), and leukemia among individuals from Norway and individuals with Scandinavian ancestry living in Utah.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the Utah Population Database and the Norwegian National Population Register linked to Cancer registries to identify cancers in children born between 1966 and 2015 and their first\u2010degree relatives. We calculated incidence rates and hazards ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of CNS tumors increased with consecutive birth cohorts similarly in Utah and Norway (both<jats:italic>P<\/jats:italic>&lt; 0.001). Incidence rates of leukemia were more stable and similar in both Utah and in Norway with 4.6\/100\u00a0000 person\u2010years among children (&lt;15 years) born in the last cohort. A family history of CNS tumors was significantly associated with risk of childhood CNS tumors in Utah HR = 3.05 (95% CI 1.80\u20105.16) and Norway HR = 2.87 (95% CI 2.20\u20103.74). In Norway, children with a first\u2010degree relative diagnosed with leukemia had high risk of leukemia (HR = 2.39, 95% CI 1.61\u20103.55).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite geographical distance and assumed large lifestyle differences, two genetically linked pediatric populations show similar incidences of CNS tumors and leukemia in the period 1966\u20132015. CNS tumors and leukemia aggregated in families in both countries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28408","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T13:09:40Z","timestamp":1590066580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Childhood central nervous system tumors and leukemia: Incidence and familial risk. A comparative population\u2010based study in Utah and Norway"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-4843","authenticated-orcid":false,"given":"Ruby","family":"Del Risco Kollerud","sequence":"first","affiliation":[{"name":"The National Centre for Occupational Rehabilitation Norway Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Cannon\u2010Albright","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hege S.","family":"Haugnes","sequence":"additional","affiliation":[{"name":"Department of Oncology University Hospital of North Norway Troms\u00f8 Norway"},{"name":"Institute of Clinical Medicine, UIT The Arctic University Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Ruud","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Division for Pediatric\u2010 and Adolescence Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magne","family":"Thoresen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Oslo Centre for Biostatistics and Epidemiology University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Nafstad","sequence":"additional","affiliation":[{"name":"Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Gerhard","family":"Blaasaas","sequence":"additional","affiliation":[{"name":"Finance Norway Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"N\u00e6ss","sequence":"additional","affiliation":[{"name":"Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rgulf","family":"Claussen","sequence":"additional","affiliation":[{"name":"Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.61.03.282"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14461"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.02.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg064"},{"key":"e_1_2_11_7_1","first-page":"390","article-title":"Tumors of the central nervous system in children and adolescents","volume":"108","author":"Fr\u00fchwald MC","year":"2011","journal-title":"DtschArztebl Int"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.04.009"},{"key":"e_1_2_11_9_1","volume-title":"History of the Scandinavian Mission","author":"Jenson A.","year":"1927"},{"key":"e_1_2_11_10_1","unstructured":"Statistics Norway.How big is the immigration to Norway \u2013 now before and internationally? 2012. 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