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Behavioral activation (BA) is an important precedent to improvements in self\u2010management and ultimately health outcomes; however, few interventions targeting BA have been developed for the SCD population. The goal of the present study was to evaluate a technology\u2010enhanced self\u2010management intervention for adolescents and young adults (AYA) with SCD targeting BA domains (ie, disease knowledge, self\u2010efficacy, motivation, and self\u2010management skills).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/methods<\/jats:title>\n                    <jats:p>Participants were randomized to one of two study arms. SCThrive participants (N =\u00a026) completed six weekly group sessions, an in\u2010person booster session, and used a companion app (iManage) to record symptoms, progress on goals, and connect with other group members. Each SCHealthEd participant (N\u00a0=\u00a027) received six weekly phone calls on SCD\u2010related and general health education topics. All AYA completed questionnaires assessing BA at baseline and posttreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Separate mixed ANOVA analyses to assess for the effects of group (SCThrive\/SCHealthEd), time (baseline\/posttreatment), and group \u00d7 time interaction indicated that there was a clinically meaningful improvement (8\u2010point change) in self\u2010efficacy, with a medium effect size,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.09,\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2\u00a0<\/jats:sup>\n                      =\u00a0.06, and there was statistically significant improvement in one self\u2010management skill (tracking health),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001,\n                      <jats:italic>d\u00a0<\/jats:italic>\n                      =\u00a0.71, among SCThrive participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results support the potential for a self\u2010management intervention to improve self\u2010efficacy in AYA with SCD. Health care providers are encouraged to target BA skills to support self\u2010management of AYA with SCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28492","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T12:26:33Z","timestamp":1595420793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Improving self\u2010management in adolescents with sickle cell disease"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-7745","authenticated-orcid":false,"given":"Lori E.","family":"Crosby","sequence":"first","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio"},{"name":"James M. 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