{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:36:55Z","timestamp":1762299415378,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In patients with sickle cell disease (SCD) and diabetes mellitus (DM), hemoglobin A<jats:sub>1c<\/jats:sub> (HbA<jats:sub>1c<\/jats:sub>) is unreliable and the American Diabetes Association recommends monitoring long\u2010term glycemia by measuring serum glucose, but use of serum fructosamine (SF), a measurement independent of red cell lifespan, has been reported. SF as a screen for DM in SCD, however, is not standardized and its relationship to serum glucose has not been validated. Further, screening for DM was not adequately addressed in the 2014 National Heart, Lung, and Blood Institute (NHLBI) guidelines for SCD management. Blood transfusions, an important treatment for some patients with SCD, can also impact HbA<jats:sub>1c<\/jats:sub>. We present a case of a patient with SCD and cystic fibrosis\u2010related diabetes on monthly chronic transfusions therapy (CTT) who had well\u2010correlated \u201csteady state\u201d HbA<jats:sub>1c<\/jats:sub> and SF levels over time, suggesting for the first time these markers may actually be useful when following long\u2010term glycemic control in patients with SCD on CTT programs.<\/jats:p>","DOI":"10.1002\/pbc.28499","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T12:05:12Z","timestamp":1593777912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemoglobin A<sub>1c<\/sub> and fructosamine correlate in a patient with sickle cell disease and diabetes on chronic transfusion therapy"],"prefix":"10.1002","volume":"67","author":[{"given":"Ashley","family":"McLean","sequence":"first","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Wright","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology  University of North Carolina School of Medicine  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"deJong","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Pediatrics Division of General Pediatrics and Adolescent Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Skinner","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Medicine Division of Hematology University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"University of North Carolina Blood Research Center  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceila E.","family":"Loughlin","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Pediatrics Division of Pediatric Pulmonology University of North Carolina School of Medicine  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Levenson","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Pediatrics Division of Pediatric Endocrinology and Diabetes University of North Carolina School of Medicine  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-3619","authenticated-orcid":false,"given":"Marcus A.","family":"Carden","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology  University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"Department of Medicine Division of Hematology University of North Carolina School of Medicine  Chapel Hill North Carolina"},{"name":"University of North Carolina Blood Research Center  Chapel Hill North 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