{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:19Z","timestamp":1786978279369,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NCTN Operations Center","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}]},{"name":"NCTN Statistics and Data Center","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}]},{"name":"Children's Oncology Group"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eyes with Group D intraocular retinoblastoma have low salvage rates. A pilot study showed safety and efficacy of sub\u2010Tenon's fascia carboplatin with systemic chemotherapy supporting further study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with newly diagnosed bilateral intraocular retinoblastoma with at least one remaining Group C or D eye were treated with six courses of carboplatin\/etoposide\/vincristine (CEV) with sub\u2010Tenon's fascia carboplatin for Group C\/D eyes during courses 2\u20104. Local ophthalmic therapy started at course 3. The primary study objective was to determine the 1\u2010year failure rate of Group D eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study closed prematurely due to poor accrual and 22 of 30 patients were evaluable for failure rate, contributing 25 Group D and four Group C eyes. Among the 25 Group D eyes, there were 13 failures within the first year of study enrollment including eight needing external beam radiotherapy (EBR) and five needing enucleation, resulting in 1\u2010year failure rate of 52%. The failure rate was significantly lower than the historical rate of 70% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.039). The 1\u2010year eye preservation rate for Group D eyes was 80% (20\/25). One\u2010year failure rate for Group C eyes was 25% (1\/4); 1\u2010year preservation rate was 100% without need for EBR. Systemic toxicity included Grade 3 hearing loss in two subjects, infections, neutropenia, and thrombocytopenia. Ocular toxicities included periorbital fat atrophy (13\/29\u00a0=\u00a045% eyes), optic nerve atrophy (1\/29\u00a0=\u00a03% eyes), and restrictive fibrosis (1\/29\u00a0=\u00a03% eyes).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sub\u2010Tenon's fascia carboplatin plus CEV was partially effective in Group D intraocular retinoblastoma but had unacceptable ocular toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28502","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T04:54:29Z","timestamp":1593233669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A single\u2010arm study of systemic and sub\u2010Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children's Oncology Group study (ARET 0231)"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7826","authenticated-orcid":false,"given":"Rima F.","family":"Jubran","sequence":"first","affiliation":[{"name":"Department of Pediatrics Children's Hospital Los Angeles Keck School of Medicine of the University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-669X","authenticated-orcid":false,"given":"Judith G.","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital Los Angeles Keck School of Medicine of the University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Krailo","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Statistical Center  Arcadia California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Piao","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Statistical Center  Arcadia California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Statistical Center  Arcadia California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Linn","family":"Murphree","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Children's Hospital Los Angeles Keck School of Medicine of the University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Gombos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology MD Anderson Cancer Center  Houston Texas"},{"name":"The Retinoblastoma Center of Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol L.","family":"Shields","sequence":"additional","affiliation":[{"name":"Will's Eye Hospital  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Meadows","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Chintagumpala","sequence":"additional","affiliation":[{"name":"The Retinoblastoma Center of Houston  Houston Texas"},{"name":"Texas Children's Cancer Center Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.138750"},{"key":"e_1_2_9_3_1","first-page":"596","article-title":"The surgical management of retinoblastoma","volume":"11","author":"Abramson DH","year":"1980","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140530002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ohc.2004.11.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.1.12"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90406-2"},{"key":"e_1_2_9_9_1","unstructured":"VillablancaJG JubranRF MurphreeLA.Phase I study of subtenon carboplatin with systemic high dose carboplatin\/etoposide\/vincristine for eyes with disseminated intraocular retinoblastoma. 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