{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:06:08Z","timestamp":1786716368982,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sickle cell disease (SCD) is associated with renal complications starting as early as infancy. Allogeneic hematopoietic stem cell transplant (HSCT) treatments using newer nonmyeloablative (NMA) conditioning regimens show promising results in treating SCD in the pediatric population, but renal outcome parameters after transplantation have not been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe baseline renal parameters as well as short\u2010 and long\u2010term renal outcomes in pediatric patients with SCD who underwent NMA\u2010HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of pediatric patients who received NMA\u2010HSCT in Alberta, Canada. Short\u2010term renal outcomes evaluated were: (1) acute kidney injury (AKI), (2) fluid overload (FO), and (3) hypertension. Long\u2010term outcomes evaluated were: (1) estimated glomerular filtration rate (eGFR) development and at last follow\u2010up with hyperfiltration defined as eGFR\u00a0\u2265\u00a0150\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>, (2) proteinuria, and (3) hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up time was 128.6\u00a0weeks (standard deviations, 69.3). No posttransplant AKI events or FO were observed. eGFR remained\u00a0&gt;\u00a090\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup> at last follow\u2010up in all patients, whereas hyperfiltration was present in eight (44.4%) and four (22.2%) patients pre\u2010 and post\u2010HSCT, respectively, which are significantly different (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Consequently, median GFR was significantly higher pre\u2010HSCT compared with 24 months HSCT (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.009). Long\u2010term hypertension post\u2010HSCT was present in six patients (33.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study describes stable kidney function in children with SCD after NMA\u2010HSCT without evidence of AKI or FO episodes. Rates of hyperfiltration decreased post\u2010HSCT, which signifies that NMA\u2010HSCT could potentially preserve long\u2010term renal function in this population at risk of progressive chronic kidney disease. Further prospective studies are needed to confirm these novel findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28568","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T16:00:23Z","timestamp":1594915223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Stable renal function in children and adolescents with sickle cell disease after nonmyeloablative hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-1043","authenticated-orcid":false,"given":"Sasia J. 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