{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:26:51Z","timestamp":1773991611675,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information on the epidemiology of pediatric liver tumors in Latin America is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the incidence of liver tumors in a pediatric registry in Argentina according to geographic region, national trends over 16\u00a0years, and survival related to stage, age, sex, and care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly diagnosed liver tumors cases are registered in the Argentine Pediatric Oncology Hospital Registry (ROHA) with an estimated coverage of 91% of national cases. Age\u2010standardized incidence rate per millon (ASR) was calculated based on the National Vital Statistics Reports. Five\u2010year overall survival (OS) was estimated using the Kaplan\u2010Meier method. The log\u2010rank test was used to compare subgroup survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred seven cases of hepatoblastoma (HB) and 73 of hepatocellular carcinoma (HCC) were identified. ASR of liver tumors was 1.8\/million (95% confidence Interval [CI], 1.6\u20102.0) per year. ASR was 1.4 (1.2\u20101.6) for HB and 0.4 (0.3\u20100.5) for HCC. For HB, the highest incidence was found in the northwest region including the Altiplano. OS was 60.4% (53.4\u201066.8) for HB and 36.1% (25.2\u201047.2) for HCC. Five\u2010year survival rate of children with metastatic HB treated at liver transplant hospitals (LTH) was 54.2% (30.3\u201073.0) compared to 13.3% (2.2\u201034.6) for those seen at other hospitals (OH) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), while for HCC this rate was 46.3% (30.7\u201060.6) at LTH compared to 17.5% (3.1\u201041.9) at OH (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence rate of pediatric liver tumors was stable over the 16\u2010year study period. Patients may benefit if at treatment initiation they are evaluated jointly with LTH specialists to define treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28583","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T06:19:23Z","timestamp":1596262763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Childhood liver tumors in Argentina: Incidence trend and survival by treatment center. A report from the national pediatric cancer registry, ROHA network 2000\u20102015"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6181-5025","authenticated-orcid":false,"given":"Florencia","family":"Moreno","sequence":"first","affiliation":[{"name":"Argentinian Pediatric Oncology Registry Ministry of Health National Cancer Institute  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Rose","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Agustina","family":"Chaplin","sequence":"additional","affiliation":[{"name":"Argentinian Pediatric Oncology Registry Ministry of Health National Cancer Institute  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Cristina","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Nacional Department of Maternity Childhood, and Adolescence, Ministry of Health  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Garc\u00eda Lombardi","sequence":"additional","affiliation":[{"name":"Ricardo Guti\u00e9rrez Children's Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Nana","sequence":"additional","affiliation":[{"name":"Ricardo Guti\u00e9rrez Children's Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Cervio","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Halac","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianela","family":"Viso","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Ayarzabal","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bosaleh","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Liberto","sequence":"additional","affiliation":[{"name":"Italian Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sarabia","sequence":"additional","affiliation":[{"name":"Dr Humberto J. Notti Children's Hospital  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Morici","sequence":"additional","affiliation":[{"name":"Alejandro Posadas National Hospital  Mor\u00f3n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Streitenberger","sequence":"additional","affiliation":[{"name":"Italian Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa G.","family":"de D\u00e1vila","sequence":"additional","affiliation":[{"name":"Garrahan Pediatric Hospital  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2015.01.010"},{"key":"e_1_2_10_3_1","unstructured":"BosmanF CarneiroF HrubanR TheiseN.WHO Classification of Tumors of Digestive System. WHO Press;2010."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2016.09.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000046"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26249"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24215"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S94008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12754"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24217"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30591"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4078-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28888"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70272-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.4857"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.06.003"},{"key":"e_1_2_10_18_1","unstructured":"Instituto Nacional de Estad\u00edstica y Censos (INDEC). Estructura de la poblaci\u00f3n [Internet].https:\/\/www.indec.gob.ar\/indec\/web\/Nivel4-Tema-2-18-77. Accessed July 27 2020."},{"key":"e_1_2_10_19_1","unstructured":"Instituto Nacional de Estad\u00edstica y Censos (INDEC). Estad\u00edsticas Vitales Informaci\u00f3n b\u00e1sica S5 (59). Argentina a\u00f1o 2015 [Internet].http:\/\/www.deis.msal.gov.ar\/wp-content\/uploads\/2016\/12\/Serie5Numero59.pdf. Accessed July 27 2020."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_10_21_1","unstructured":"International Agency for Research on Cancer.International Incidence of Childhood Cancer 3. World Health Organization.http:\/\/iicc.iarc.fr\/results\/comparative.php. Accessed July 27 2020."},{"issue":"6","key":"e_1_2_10_22_1","first-page":"440","article-title":"Variaci\u00f3n altitudinal del peso al nacer en la provincia de Jujuy","volume":"100","author":"Alvarez PB","year":"2002","journal-title":"Archargentpediatr"},{"issue":"2","key":"e_1_2_10_23_1","first-page":"55","article-title":"[Effect of high altitude on birth weight and adverse perinatal outcomes in two Argentine populations]","volume":"70","author":"Grandi C","year":"2013","journal-title":"Rev Fac Cienc Medicas Cordoba Argent"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12112"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/670728"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23069"},{"key":"e_1_2_10_27_1","unstructured":"National Cancer Institute.Age\u2010Adjusted and Age\u2010Specific SEER Cancer Incidence Rates 2011\u20102015. National Cancer Institute.https:\/\/seer.cancer.gov\/archive\/csr\/1975_2015\/results_merged\/sect_29_childhood_cancer_iccc.pdf. Accessed July 27 2020."},{"key":"e_1_2_10_28_1","unstructured":"KaatschP GrabowD SpixC.German Childhood Cancer Registry \u2010 Annual Report 2017 (1980\u20102016) [Internet]. 2018:1\u2010154.http:\/\/link.springer.com\/10.1007\/s00761-013-2520-2. Accessed July 27 2020."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12699"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.023"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12239.1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.04.024"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.28583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28583","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T20:54:36Z","timestamp":1693860876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/pbc.28583"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28583","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"2019-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28583"}}