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Our results show that <jats:italic>CTNNB1<\/jats:italic> circulating tumour DNA (ctDNA) is readily detected in patients diagnosed with localised HBL, with serial sampling along the course of therapy and follow up providing a sensitive mechanism to monitor tumour dynamics and response to treatment. This exciting potential for <jats:italic>CTNNB1<\/jats:italic> ctDNA to serve as a biomarker for treatment response in HBL holds clinical value, and requires assessment in a larger cohort of mixed tumour stages and recurrent disease.<\/jats:p>","DOI":"10.1002\/pbc.28594","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T05:22:35Z","timestamp":1599110555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploration of <i>CTNNB1<\/i> ctDNA as a putative biomarker for hepatoblastoma"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-4310","authenticated-orcid":false,"given":"Smadar","family":"Kahana\u2010Edwin","sequence":"first","affiliation":[{"name":"Children's Cancer Research Unit, Kids Research The Children's Hospital at Westmead  Westmead New South Wales 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