{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:55:19Z","timestamp":1790153719022,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The International Soft\u2010Tissue Sarcoma Consortium (INSTRuCT) was founded as an international collaboration between different pediatric soft\u2010tissue sarcoma cooperative groups (Children's Oncology Group, European Pediatric Soft\u2010Tissue Sarcoma Group, and Cooperative Weichteilsarkom Studiengruppe). Besides other tasks, a major goal of INSTRuCT is to develop consensus expert opinions for best clinical treatment. This consensus paper for patients with rhabdomyosarcoma of the female genital tract (FGU\u2010RMS) provides treatment recommendations for local treatment, long\u2010term follow\u2010up, and fertility preservation. Therefore, a review of the current literature was combined with recommendations of the treatment protocols of the appropriate clinical trials. Additionally, opinions of international FGU\u2010RMS experts were incorporated into recommendations. Results were that the prognosis of FGU\u2010RMS is favorable with an excellent response to chemotherapy. Initial complete surgical resection is not indicated, but diagnosis should be established properly. In patients with tumors localized at the vagina or cervix demonstrating incomplete response after induction chemotherapy, local radiotherapy (brachytherapy) should be carried out. In patients with persistent tumors at the corpus uteri, hysterectomy should be performed. Fertility preservation should be considered in all patients. In conclusion, for the first time, an international consensus for the treatment of FGU\u2010RMS patients could be achieved, which will help to harmonize the treatment of these patients in different study groups.<\/jats:p>","DOI":"10.1002\/pbc.28601","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T19:02:44Z","timestamp":1596740564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Local treatment of rhabdomyosarcoma of the female genital tract: Expert consensus from the Children's Oncology Group, the European Soft\u2010Tissue Sarcoma Group, and the Cooperative Weichteilsarkom Studiengruppe"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-6509","authenticated-orcid":false,"given":"Timothy B.","family":"Lautz","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Bicetre Hospital, Assistance Publique\u2010Hopitaux de Paris Hopitaux Universitaires Paris\u2010Sud  Le Kremlin Bicetre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology University Children's Hospital  Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Brachytherapy Unit, Gustave Roussy Cancer Campus  Villejuif 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