{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:15:40Z","timestamp":1770711340607,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this single\u2010center observational study was to determine the clinical and hematologic responses to intravenous ferric carboxymaltose (FCM) in a cohort of pediatric patients with poor response to oral iron therapy. The occurrence of adverse events was systematically recorded for up to 96\u00a0hours after infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>A retrospective cohort of 144 consecutive patients aged 18 months to\u00a0&lt;\u00a018 years with iron deficiency anemia (IDA) or iron deficiency (ID) without anemia was investigated. All patients had failed oral iron therapy. The assessments before and after FCM treatment followed a predefined protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred of 117 (85 %) of patients with complete data achieved the target ferritin level\u00a0\u2265\u00a030 \u00b5g\/L after a single FCM dose. Of 77 patients with IDA and complete data, 38 (49%) showed a complete hematological response within 6\u201012\u00a0weeks; a complete or partial response was achieved by 83%. Clinical symptoms improved in 85% of all patients. In 92% of patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0133 \/144), FCM infusion was uneventful. During the 96\u2010hour follow\u2010up, five patients reported potentially related symptoms. No serious adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study confirms the safety and efficacy of FCM in children (aged 18\u00a0months and older) and adolescents unresponsive to oral therapy, in real\u2010world experience. Single\u2010dose FCM treatment was followed by clinical improvement with advantages of safety, compliance, and lower cost compared with previous generation parenteral iron preparations that had to be administered in fractionated sessions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28614","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T07:42:05Z","timestamp":1596094925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-3062","authenticated-orcid":false,"given":"Hulya","family":"Ozsahin","sequence":"first","affiliation":[{"name":"Centre de P\u00e9diatrie, Clinique des Grangettes  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