{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:00:00Z","timestamp":1771484400745,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bilateral retinoblastoma (Rb) treatment remains a challenge for ophthalmologists and pediatric oncologists despite new therapeutic strategies for eye preservation. The purpose of this work is to evaluate treatment outcomes in patients who underwent eye salvage treatment at a single\u2010center prior to the chemotherapy in situ era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We followed a cohort of 88 consecutive Rb patients diagnosed at Hospital Infantil de M\u00e9xico between November 2000 and June 2014. Eye salvage treatment consisted of systemic chemotherapy plus focal therapy planned by a multidisciplinary team. Unresponsive tumors were treated with episcleral brachytherapy and external beam radiotherapy (EBRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 96 eyes underwent eye salvaging therapy. Seventy\u2010eight eyes (81%) were salvaged. Seven patients (8%) required brachytherapy and 34 patients (39%) underwent EBRT. Thirty\u2010three of 78 preserved eyes (42%) achieved normal visual acuity: 5\/27 (20%) in radiated patients and 28\/51 (61%) in nonradiated patients. Eight patients developed secondary primary malignancies; however, those treated with EBRT did not have a significantly increased risk when compared with nonirradiated patients (OR: 1.66; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.492). The overall survival rate was 86% (95% CI, 76%\u201092%) after a mean follow\u2010up of 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Eye preservation, long\u2010term tumor control, and functional visual acuity could be maintained in many child and adolescent Rb survivors. Our data suggest that ocular radiotherapy can be used as consolidation treatment when other recently developed therapies with potentially fewer side effects are not available. Multidisciplinary management of Rb is mandatory to obtain cancer control during eye salvage treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28625","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T08:55:59Z","timestamp":1596444959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ocular preservation in patients with bilateral retinoblastoma before chemotherapy in situ era: A report from a Mexican Retinoblastoma Reference Hospital"],"prefix":"10.1002","volume":"67","author":[{"given":"Zaira","family":"del Carmen Bernal\u2010D\u00edaz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Hospital Infantil de M\u00e9xico Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Murillo\u2010Maldonado","sequence":"additional","affiliation":[{"name":"Department of Oncology Hospital Infantil de M\u00e9xico Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heynar","family":"P\u00e9rez\u2010Villanueva","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Hospital Infantil de M\u00e9xico Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Reyes\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Center for Economic Studies in Health Hospital Infantil de M\u00e9xico Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-502X","authenticated-orcid":false,"given":"Marco A.","family":"Ram\u00edrez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Infantil de M\u00e9xico Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.150292"},{"key":"e_1_2_10_3_1","first-page":"41","article-title":"Systematic review of the current status of programs and general knowledge of diagnosis and management of retinoblastoma","volume":"74","author":"Ram\u00edrez\u2010Ortiz MA","year":"2017","journal-title":"Bol Med Hosp Infant Mex"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2016.1154177"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.168062"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-1069"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25048"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24265"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.12.030"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.05.005"},{"key":"e_1_2_10_11_1","first-page":"726","article-title":"Use of intra\u2010arterial chemotherapy for retinoblastoma: results of a survey","volume":"7","author":"Grigorovski N","year":"2014","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27024"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25781"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ohc.2004.11.003"},{"key":"e_1_2_10_15_1","first-page":"977","article-title":"Treatment of retinoblastoma with cryotherapy","volume":"42","author":"Shields JA","year":"1990","journal-title":"Trans Pa Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140548005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.037044"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.1.12"},{"key":"e_1_2_10_19_1","unstructured":"World Health Organization: International Statistical Classification of Diseases and Related Health Problems. 10th revision. 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