{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:25:50Z","timestamp":1762431950422,"version":"3.41.2"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aerodigestive adverse effects (AD\u2010AE) during intravenous pentamidine (IV\u2010P) infusion for <jats:italic>Pneumocystis jiroveci<\/jats:italic> pneumonia prophylaxis are uncommon in retrospective chart review studies. We conducted a survey in patients on IV\u2010P, which included 31 specific questions. Twenty\u2010five patients were included in the analysis; AD\u2010AE were observed in 22 (88%) with recurrence of symptoms in 88% participants with subsequent infusions. Five leading symptoms were congestion (48%), lip tingling (32%), nausea (28%), tongue tingling (24%), vomiting, and throat swelling (17%); multiple symptoms were reported in 72% of the patients. In conclusion, AD\u2010AE of IV\u2010P infusion are common, self\u2010limited, and tend to be recurrent.<\/jats:p>","DOI":"10.1002\/pbc.28714","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T16:46:39Z","timestamp":1601138799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aerodigestive adverse effects during intravenous pentamidine infusion for <i>Pneumocystis jirovecii<\/i> pneumonia prophylaxis"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-3027","authenticated-orcid":false,"given":"S\u00fcreyya","family":"Sava\u015fan","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Michigan Detroit Medical Center  Detroit Michigan"},{"name":"Division of Hematology\/Oncology Department of Pediatrics Pediatric Bone Marrow Transplantation Program Children's Hospital of Michigan Barbara Ann Karmanos Cancer Center Central Michigan University College of Medicine  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"George","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Michigan Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Michigan Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-8565","authenticated-orcid":false,"given":"Bettina Joi","family":"McGraw","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Michigan Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Michigan Detroit Medical Center  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"e00173","DOI":"10.1128\/AAC.00173-18","article-title":"Pentamidine for prophylaxis against Pneumocystis jirovecii pneumonia in pediatric oncology patients receiving immunosuppressive chemotherapy","volume":"62","author":"Quinn M","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26453","article-title":"The use of intravenous pentamidine for the prophylaxis of Pneumocystis pneumonia in pediatric patients","volume":"64","author":"Kruizinga MD","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000946"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12441"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02439"},{"key":"e_1_2_8_7_1","first-page":"e1598","article-title":"Pathogenesis of drug induced non\u2010allergic angioedema: a review of unusual etiologies","volume":"9","author":"Kalambay J","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"197\u2010199","DOI":"10.1177\/106002809402800208","article-title":"Cyclophosphamide\u2010induced facial discomfort","volume":"28","author":"Kosirog\u2010Glowacki JL","year":"1994","journal-title":"Ann Pharmacother"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"S48\u2010S51","article-title":"Chapter 14: nonallergic rhinitis","volume":"27","author":"Settipane RA","year":"2013","journal-title":"Am J Rhinol Allergy"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:34:34Z","timestamp":1693737274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,26]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/pbc.28714"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28714","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2020,9,26]]},"assertion":[{"value":"2020-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28714"}}