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Protocol therapy was nearly identical for patients with T\u2010ALL (N\u00a0=\u00a0123), who were all initially assigned to the high\u2010risk arm. End\u2010induction minimal residual disease (MRD) was assessed by reverse transcription polymerase chain reaction (RT\u2010PCR) or next\u2010generation sequencing (NGS), but was not used to modify postinduction therapy. Early T\u2010cell precursor (ETP) status was determined by flow cytometry. Cases with sufficient diagnostic DNA were retrospectively evaluated by targeted NGS of known genetic drivers of T\u2010ALL, including Notch, PI3K, and Ras pathway genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year event\u2010free survival (EFS) and overall survival (OS) for patients with T\u2010ALL was 81% (95% CI, 73\u201087%) and 90% (95% CI, 83\u201094%), respectively. ETP phenotype was associated with failure to achieve complete remission, but not with inferior OS. Low end\u2010induction MRD (&lt;10<jats:sup>\u22124<\/jats:sup>) was associated with superior disease\u2010free survival (DFS). Pathogenic mutations of the PI3K pathway were mutually exclusive of ETP phenotype and were associated with inferior 5\u2010year DFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Together, our findings demonstrate that ETP phenotype, end\u2010induction MRD, and PI3K pathway mutation status are prognostically relevant in pediatric T\u2010ALL and should be considered for risk classification in future trials. DFCI Protocols 05\u2010001 and 11\u2010001 are registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link> as NCT00165087 and NCT01574274, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28719","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T15:37:11Z","timestamp":1602085031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Identification of prognostic factors in childhood T\u2010cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocols 05\u2010001 and 11\u2010001"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-766X","authenticated-orcid":false,"given":"Melissa A.","family":"Burns","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Dana\u2010Farber Cancer Institute Harvard 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