{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:38:33Z","timestamp":1775554713870,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18ek0510023h0002"],"award-info":[{"award-number":["18ek0510023h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The appropriateness of allogeneic hematopoietic stem cell transplantation (HSCT) in children and adolescents with leukemia in whom complete remission is not possible remains unclear. This retrospective analysis aimed to investigate the outcomes associated with HSCT, and the risks of HSCT in children and adolescents with nonremission acute lymphoblastic leukemia (ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Data from the Japan Society for Hematopoietic Cell Transplantation registry on 325 patients with nonremission ALL (aged &lt;21\u00a0years, with blasts in the peripheral blood and\/or bone marrow) who had undergone HSCT between January 2001 and December 2015 were evaluated. To assess survival, we developed a scoring system using significant adverse pre\u2010HSCT variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 247 patients died. The median length of follow up among survivors was 1145\u00a0days, and the 3\u2010year overall survival was 22% (95% confidence interval [CI]: 18\u201027%). A low performance score, presence of &gt;25% bone marrow blasts, T\u2010cell phenotype, poor\u2010risk or normal cytogenetics, and history of HSCT were predictors of a poor outcome. Patients scoring 0\u20101 (n\u00a0=\u00a0109), 2 (n\u00a0=\u00a091), and 3\u20107 (n\u00a0=\u00a0125) had a 3\u2010year overall survival of 41% (95% CI: 31\u201051%), 21% (95% CI: 13\u201031%), and 7% (95% CI: 3\u201012%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results support HSCT in certain nonremission patients. Even in patients without complete remission, outcomes differed according to pre\u2010HSCT factors. A scoring system could help determine the appropriateness of HSCT in children and adolescents with nonremission ALL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28732","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T13:19:32Z","timestamp":1600780772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hematopoietic stem cell transplantation in children and adolescents with nonremission acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-6441","authenticated-orcid":false,"given":"Yasuhiro","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima 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