{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:40:05Z","timestamp":1788381605222,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study is to evaluate demographics, clinical data, and survival rates of children with cancer over 22\u00a0years, and to compare the outcomes, before and after a national health reform was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Files of patients, aged 0\u201019\u00a0years, diagnosed with cancer at the Istanbul University Oncology Institute during 1990\u20102012 were evaluated retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age at diagnosis of 2413 patients was 7.5\u00a0\u00b1\u00a05.1\u00a0years (range 3\u00a0days to 19\u00a0years). Male\/female ratio was 1.26. After 2002, the number of patients diagnosed at a localized\/low\u2010risk stage compared to advanced stage significantly increased (60.7% vs 65.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03). Comparing the period before 2002 to after 2002, a lower percentage of patients were diagnosed with advanced stage non\u2010Hodgkin lymphoma (62.1% vs 45.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03), retinoblastoma (9.5% vs 1.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005), soft tissue sarcomas (52.1% vs 38.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01), neuroblastoma (82.4% vs 56.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005), and carcinomas (72.9% vs 65.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04) after 2002. The 5\u2010year survival rate of all patients during the entire period was 74.4%. The survival rate significantly increased for non\u2010Hodgkin lymphoma (63.7% vs 91.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001), neuroblastoma (46.8% vs 70.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.025), and renal tumors (70% vs 92.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.013) after 2002.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increase in patients diagnosed at a localized\/low\u2010risk stage and the increase in survival of some types of cancer over years is promising. The national health care reform, enabling patients to easily access free health services, increased awareness, improvement in oncological treatment, and supportive care may have contributed to the progress achieved, and may be a model for other developing countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28754","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T22:36:58Z","timestamp":1602196618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Epidemiology and survival of childhood cancer in Turkey"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-8174","authenticated-orcid":false,"given":"Rejin","family":"Kebudi","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Clinical Oncology &amp; Department of Preventive Oncology Oncology Institute Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek Uludag","family":"Alkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32835c1cbe"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70008-1"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1744-8603-8-34","article-title":"Cancer registries in four provinces in Turkey: a case study","volume":"8","author":"Stillman FA","year":"2012","journal-title":"Global Health"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9288-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318249aaac"},{"issue":"5","key":"e_1_2_9_7_1","article-title":"Turkish national pediatric cancer registry 2002\u20102008 (Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Society)","volume":"53","author":"Kutluk T","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61051-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0284-9_17"},{"issue":"15","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"10050","DOI":"10.1200\/jco.2015.33.15_suppl.10050","article-title":"Efficacy in six courses of nonmethotrexate three\u2010drug chemotherapy and surgery in osteosarcoma: 25\u2010year experience","volume":"33","author":"Kebudi R","year":"2015","journal-title":"J Clin Oncol"},{"issue":"15","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"e22009","DOI":"10.1200\/JCO.2017.35.15_suppl.e22009","article-title":"Advances in the approach to treatment of bilateral retinoblastoma: 26\u2010year experience","volume":"35","author":"Kebudi R","year":"2017","journal-title":"J Clin Oncol"},{"key":"e_1_2_9_13_1","unstructured":"RiesLAG SmithMA GurneyJ et\u00a0al.Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975\u20101995. 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Bethesda MD: NIH;1999."},{"issue":"15","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"e22015","DOI":"10.1200\/JCO.2017.35.15_suppl.e22015","article-title":"Pediatric cancer registry Turkey: 2009\u20102016 (TPOG & TPHD)","volume":"35","author":"Kutluk MT","year":"2017","journal-title":"J Clin Oncol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-319-22912-6_12","volume-title":"Cancer Care in Countries and Societies in Transition","author":"Kebudi R","year":"2016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-S1-S8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70548-5"},{"issue":"2","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4103\/0973-1482.183205","article-title":"Treatment of high\u2010risk neuroblastoma: national protocol results of the Turkish Pediatric Oncology Group","volume":"13","author":"Aksoylar S","year":"2017","journal-title":"J Cancer Res Ther"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:44:11Z","timestamp":1693748651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/pbc.28754"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28754","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"assertion":[{"value":"2019-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28754"}}