{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:44:16Z","timestamp":1778528656155,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data for visual acuity (VA) after treatment of neurofibromatosis type 1\u2010associated optic pathway gliomas (NF1\u2010OPGs) are limited. We retrospectively collected VA, converted to logMAR, before and after targeted therapy with everolimus for NF1\u2010OPG, and compared to radiologic outcomes (14\/18 with NF1\u2010OPG, 25 eyes [three without quantifiable vision]). Upon completion of treatment, VA was stable in 19 eyes, improved in four eyes, and worsened in two eyes; visual and radiologic outcomes were discordant. In summary, the majority of children with NF1\u2010OPG exhibited stabilization of their VA after everolimus treatment. A larger, prospective study will help delineate visual outcomes after targeted therapy.<\/jats:p>","DOI":"10.1002\/pbc.28833","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T17:10:24Z","timestamp":1608311424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Visual outcomes following everolimus targeted therapy for neurofibromatosis type 1\u2010associated optic pathway gliomas in children"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-3362","authenticated-orcid":false,"given":"Nicole J.","family":"Ullrich","sequence":"first","affiliation":[{"name":"Department of Neurology Boston Children's Hospital  Boston Massachusetts"},{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorder Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-115X","authenticated-orcid":false,"given":"Sanjay P.","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-7531","authenticated-orcid":false,"given":"Roger J.","family":"Packer","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Behavioral Medicine Children's National Hospital  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0134-1352","authenticated-orcid":false,"given":"Stewart","family":"Goldman","sequence":"additional","affiliation":[{"name":"Ann and Robert Lurie Children's Hospital  Chicago 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Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-5045","authenticated-orcid":false,"given":"David H.","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-8226","authenticated-orcid":false,"given":"John P.","family":"Perentesis","sequence":"additional","affiliation":[{"name":"Division of Oncology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-339X","authenticated-orcid":false,"given":"Bruce R.","family":"Korf","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-3839","authenticated-orcid":false,"given":"Michael J.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-7692","authenticated-orcid":false,"given":"Mark W.","family":"Kieran","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorder Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"NF Clinical Trials 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