{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:02:54Z","timestamp":1787065374119,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pediatric oncology patients undergoing active chemotherapy are suspected to be at a high risk for severe disease secondary to severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) infection; however, data to support this are lacking. We aim to describe the characteristics of coronavirus disease 2019 (COVID\u201019) in this population and also its impact on pediatric cancer care in the New York region during the peak of the pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective study included 13 institutions. Clinical and laboratory information on 98 patients \u226421\u00a0years of age receiving active anticancer therapy, who tested positive for SARS\u2010CoV\u20102 by nasopharyngeal swab polymerase chain reaction (PCR), was collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 578 pediatric oncology patients tested for COVID\u201019, 98 were positive, of whom 73 were symptomatic. Most experienced mild disease, 28 required inpatient management, 25 needed oxygen support, and seven required mechanical ventilation. There is a slightly higher risk of severe disease in males and obese patients, though not statistically significant. Persistent lymphopenia was noted in severe cases. Delays in cancer therapy occurred in 67% of SARS\u2010CoV\u20102\u2010positive patients. Of four deaths, none were solely attributable to COVID\u201019. The impact of the pandemic on pediatric oncology care was significant, with 54% of institutions reporting delays in chemotherapy, 46% delays in surgery, and 30% delays in transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large multi\u2010institutional cohort, we observed that mortality and morbidity from COVID\u201019 amongst pediatric oncology patients were low overall, but higher than reported in general pediatrics. Certain subgroups might be at higher risk of severe disease. Delays in cancer care due to SARS\u2010CoV\u20102 remain a concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28843","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T16:45:31Z","timestamp":1608309931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Characterization of COVID\u201019 disease in pediatric oncology patients: The New York\u2010New Jersey regional experience"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-4393","authenticated-orcid":false,"given":"P. 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Sanzari Children's Hospital Hackensack University Medical Center  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology and Cellular Therapy Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-1791","authenticated-orcid":false,"given":"Adit","family":"Tal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology and Cellular Therapy Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stony Brook Children's Hospital  Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Feinberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\u2010Oncology at Maimonides Cancer Center Maimonides Medical Center  Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Kahn","sequence":"additional","affiliation":[{"name":"The Valerie Fund Center at St. Joseph's Children's Hospital  Paterson New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Pinchinat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology Oncology and Stem Cell Transplantation Maria Fareri Children's Hospital at Westchester Medical Center New York Medical College  Valhalla New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teena","family":"Bhatla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\u2010Oncology Children's Hospital of New Jersey at Newark Beth Israel Medical Center  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chana L.","family":"Glasser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\u2010Oncology NYU Winthrop Hospital NYU Long Island School of Medicine  Mineola New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Satwani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology Oncology, and Stem Cell Transplantation New York\u2010Presbyterian Morgan Stanley Children's Hospital Columbia University Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Raetz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\u2010Oncology Hassenfeld Children's Hospital at NYU Langone Health Perlmutter Cancer Center NYU Grossman School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Onel","sequence":"additional","affiliation":[{"name":"Departments of Genetics and Genomic Sciences Medicine Pathology and Pediatrics Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\u2010Oncology Hassenfeld Children's Hospital at NYU Langone Health Perlmutter Cancer Center NYU Grossman School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30096-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2005073"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28392"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28432"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.2028"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28420"},{"key":"e_1_2_10_8_1","unstructured":"American Society of Hematology Research Collaborative (ASH RC).COVID\u201019 Registry in Hematology. 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