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This pilot study sought to determine if a dietary intervention is feasible and minimizes weight gain during the initial phases of treatment for ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited from four institutions, fluent in English or Spanish, between 5 and 21\u00a0years old, and enrolled within 3\u00a0days of starting induction therapy. Participants were counseled for 6\u00a0months to follow a low glycemic diet. Dietary and anthropometric data were collected at diagnosis, end of induction, and end of month 6 (NCT03157323).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three of 28 participants (82.1%) were evaluable and included in the analysis. Dietary changes targeted by the nutrition intervention were successful; sugar intake declined (<jats:italic>P<\/jats:italic>\u00a0=\u00a0<jats:bold>.00<\/jats:bold>3), whereas vegetable intake increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a0<jats:bold>.0<\/jats:bold>33). The majority of participants were able to adhere to the dietary principles prescribed: \u226570.0% reduced glycemic load and \u226560.0% increased fiber intake and decreased sugar intake. Importantly, we did not observe an increase in body mass index <jats:bold><jats:italic>z<\/jats:italic><\/jats:bold>\u2010score during induction or over the 6\u2010month intervention period. Most families found the nutrition intervention easy to follow (60%) and affordable (95%) despite simultaneous initiation of treatment for ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 6\u2010month nutrition intervention initiated during the initial phase of treatment for childhood ALL is feasible and may prevent weight gain. Our preliminary findings need to be confirmed in a larger clinical trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28910","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T17:52:34Z","timestamp":1613670754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A bilingual dietary intervention early in treatment is feasible and prevents weight gain in childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2908-6779","authenticated-orcid":false,"given":"Michelle","family":"Walters","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/Stem Cell Transplant Columbia University Irving Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Mowbray","sequence":"additional","affiliation":[{"name":"Division of Oncology 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