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Right and left ventricular (RV, LV) myocardial strain are early markers of systolic dysfunction but are not well investigated among individuals with SCD. The objectives of this review were to (1) identify all published studies that have evaluated ventricular myocardial strain, (2) summarize their values, and (3) compare findings with those obtained from controls. From search results of four electronic databases\u2014Medline, Embase, Scopus, and Web of Science\u201442 potential articles were identified, of which 18 articles and 17 studies met eligibility criteria for inclusion. The evaluated studies demonstrate that RV and LV myocardial strain are generally abnormal in individuals with SCD compared with controls, despite having normal ejection\/shortening fraction. Myocardial strain has been inconsistently evaluated in this population and should be considered any time an echocardiogram is performed.<\/jats:p>","DOI":"10.1002\/pbc.28973","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T06:49:47Z","timestamp":1616222987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sickle cell disease and ventricular myocardial strain: A systematic review"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-2002","authenticated-orcid":false,"given":"Nicholas S.","family":"Whipple","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Primary Children's Hospital University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya M.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics University of Tennessee College of Medicine  Memphis Tennessee USA"},{"name":"Cardiopulmonary Services St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak J.","family":"Naik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics University of Tennessee College of Medicine  Memphis Tennessee USA"},{"name":"Cardiopulmonary Services St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-188X","authenticated-orcid":false,"given":"Tisha","family":"Mentnech","sequence":"additional","affiliation":[{"name":"North Carolina State University Libraries  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McFarland","sequence":"additional","affiliation":[{"name":"Eccles Health Sciences Library University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki G.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.12.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001484"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709113371107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200203000-00003"},{"key":"e_1_2_8_7_1","volume-title":"Nathan and Oski's Hematology and Oncology of Infancy and Childhood","author":"Orkin SFD","year":"2015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21569"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24557"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.038"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800206"},{"key":"e_1_2_8_13_1","unstructured":"SteinerCA MillerJL. 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