{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:21:53Z","timestamp":1790446913095,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limited data are available regarding radiation therapy in pediatric pleuropulmonary blastoma (PPB). We report the case of a 3\u2010year\u2010old girl with type II PPB successfully treated with trimodality therapy including multiagent chemotherapy, resection, and whole pleura radiation therapy. While longer follow\u2010up is required to confirm ultimate local tumor control and long\u2010term post\u2010treatment sequelae, currently 3.5\u00a0years following therapy, she is well, without recurrent disease or observable toxicity. The goal of this report is to add our experience to the literature regarding PPB, its management, and treatment, as prospective randomized controlled trials are not feasible due to the rarity of this disease.<\/jats:p>","DOI":"10.1002\/pbc.29004","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T11:31:50Z","timestamp":1615375910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multimodality treatment including whole pleura radiation therapy for DICER1\u2010associated pediatric pleuropulmonary blastoma"],"prefix":"10.1002","volume":"68","author":[{"given":"Caressa","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle H.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Wakeling","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetic Counseling University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7125-3118","authenticated-orcid":false,"given":"Sarah S.","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florette K.","family":"Hazard","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Rangaswami","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4723-2151","authenticated-orcid":false,"given":"Susan M.","family":"Hiniker","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10050143"},{"key":"e_1_2_5_3_1","unstructured":"U.S. National Library of Medicine.International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01464606. 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