{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:20Z","timestamp":1786978280654,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood cancer survivors (CCS) have increased risk of developing chronic health conditions, including musculoskeletal disorders. Little is known regarding vitamin D deficiency (VDD,\u00a0&lt;20\u00a0ng\/ml) and its association with bone mineral density (BMD) in long\u2010term CCS. We evaluated the prevalence and risk factors for VDD in a large, diverse population of long\u2010term CCS, and examined the association between VDD and BMD in patients who underwent guideline\u2010recommended dual\u2010energy X\u2010ray absorptiometry (DXA) screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 446 consecutive CCS seen from March 2018 to September 2020. Univariate analyses examined associations between CCS demographics, socioeconomic status, and treatment exposures and VDD. Multivariable logistic regressions identified factors associated with odds of VDD and reduced BMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age at evaluation was 27.5 years (range 7\u201367 years); median time from completing therapy was 14.2 years (range 2\u201365 years). Fifty percent were female, and 45% were Hispanic. Twenty\u2010four percent had VDD. In multivariable analysis, overweight and obese BMI were associated with VDD (overweight: OR 1.78, 95% CI 1.03\u20133.07,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.04; obese: OR 2.40, 95% CI 1.39\u20134.13,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01; reference: normal\/underweight), as was Hispanic or black race\/ethnicity (OR 2.40, 95% CI 1.41\u20134.09,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01; reference: non\u2010Hispanic white). In the 118 CCS with DXA results, VDD was independently associated with reduced BMD (OR 3.58, 95%CI 1.33\u20139.59,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CCS have a high prevalence of VDD. High BMI and Hispanic or black race\/ethnicity were associated with VDD. Survivors with VDD had a greater than threefold risk of reduced BMD. Risk\u2010based screening may facilitate timely interventions to mitigate VDD and improve BMD in CCS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.29048","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T10:19:54Z","timestamp":1617704394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence and risk factors for vitamin D deficiency in long\u2010term childhood cancer survivors"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-1518","authenticated-orcid":false,"given":"Rusha","family":"Bhandari","sequence":"first","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"},{"name":"Department of Pediatrics City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Berano","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Echevarria","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanie","family":"Lindenfeld","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Lennie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saro H.","family":"Armenian","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Comprehensive Cancer Center  Duarte California USA"},{"name":"Department of Pediatrics City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3634"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32512"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.6545"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2017.07.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30159-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1119-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.238261"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.12.704"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2878-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518000491"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0051"},{"key":"e_1_2_10_15_1","unstructured":"BMI Percentile Calculator for Child and Teen. 2019.https:\/\/www.cdc.gov\/healthyweight\/bmi\/calculator.html. Accessed October 26 2020."},{"key":"e_1_2_10_16_1","unstructured":"About Adult BMI. 2020.https:\/\/www.cdc.gov\/healthyweight\/assessing\/bmi\/adult_bmi\/index.html#InterpretedAdults. Accessed October 26 2020."},{"key":"e_1_2_10_17_1","volume-title":"Long\u2010Term Follow\u2010Up Guidelines for Survivors of Childhood, Adolescent and Young Adult Cancers, Version 5.0","author":"Children's Oncology Group","year":"2018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0153-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2398"},{"key":"e_1_2_10_20_1","unstructured":"Food Access Research Atlas.https:\/\/www.ers.usda.gov\/data\u2010products\/food\u2010access\u2010research\u2010atlas\/go\u2010to\u2010the\u2010atlas\/. 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