{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:38:50Z","timestamp":1770989930852,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Diffuse intrinsic pontine glioma (DIPG) is a rare and aggressive childhood brainstem malignancy with a 2\u2010year survival rate of &lt;10%. This international survey study aims to evaluate the use of complementary and alternative medicine (CAM) in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Parents and physicians of patients with DIPG were asked to participate in a retrospective online survey regarding CAM use during time of illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January and May 2020, 120 parents and 75 physicians contributed to the online survey. Most physicians estimated that &lt;50% of their patients used CAM, whereas 69% of the parents reported using CAM to treat their child during time of illness. Cannabis was the most frequently used form of CAM, followed by vitamins and minerals, melatonin, curcumin, and boswellic acid. CAM was mainly used with the intention of direct antitumor effect. Other motivations were to treat side effects of chemotherapy or to increase comfort of the child. Children diagnosed from 2016 onwards were more likely to use CAM (\u03c7<jats:sup>2\u00a0<\/jats:sup>=\u00a06.08, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014). No significant difference was found between CAM users and nonusers based on ethnicity (\u03c7<jats:sup>2\u00a0<\/jats:sup>=\u00a04.18, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.382) or country of residence (\u03c7<jats:sup>2\u00a0<\/jats:sup>=\u00a09.37, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.154). Almost 50% of the physicians do not frequently ask their patients about possible CAM use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This survey demonstrates that worldwide, a considerable number of patients with DIPG use CAM. Physicians should be more aware of potential CAM use and actively discuss the topic. In addition, more research is needed to gain knowledge about possible anticancer effects of CAM and (positive\/negative) interactions with conventional therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29061","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T08:31:16Z","timestamp":1620117076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Complementary and alternative medicine in children with diffuse intrinsic pontine glioma\u2014A SIOPE DIPG Network and Registry study"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-8516","authenticated-orcid":false,"given":"Fatma E.","family":"El\u2010Khouly","sequence":"first","affiliation":[{"name":"Pediatric Oncology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed M.","family":"Adil","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wiese","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Division of Pediatric Hematology and Oncology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Hulleman","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Harry","family":"Hendrikse","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Clinical Pharmacology and Pharmacy Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertjan J.L.","family":"Kaspers","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-926X","authenticated-orcid":false,"given":"Christof M.","family":"Kramm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Division of Pediatric Hematology and Oncology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie E.M.","family":"Veldhuijzen van Zanten","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dannis G.","family":"van Vuurden","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SIOPE DIPG Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011215)92:12<3155::AID-CNCR10158>3.0.CO;2-C"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-2-197"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70615-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.9308"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00263825"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1279"},{"key":"e_1_2_9_9_1","unstructured":"National Center for Complementary and Integrative Health.Complementary Alternative or Integrative Health: What's In a Name?U.S. Department of Health and Human Services;2020.https:\/\/nccih.nih.gov\/health\/integrative\u2010health. 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