{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:01:56Z","timestamp":1760101316517,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have explored posthematopoietic cell transplant (HCT) outcomes by race in adults; however, pediatric data addressing this topic are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This retrospective registry study included 238 White (W) and 57 Black (B) children with hematologic malignancies (HM) receiving first allogeneic HCT between 2010 and 2019 at one of the five Florida pediatric HCT centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no differences between W and B children in transplant characteristics, other than donor type. There was a significant difference in use of human leukocyte antigen (HLA)\u2010mismatched donors (HLA\u2010MMD) (53% W, 71% B, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.01). When comparing HLA\u2010MMD use to fully HLA\u2010matched donors, B had relative risk (RR) of 1.47 (95% CI 0.7\u20133) of receiving a mismatched unrelated donor (MMUD), RR of 2.34 (95% CI 1.2\u20134.4) of receiving a mismatched related donor (MMRD), and RR of 1.9 (95% CI 0.99\u20133.6) of receiving a mismatched cord blood donor (MMCBD) HCT, respectively. There was no significant difference in the incidence of aGVHD (48% W, 35% B), <jats:italic>p<\/jats:italic>\u00a0=\u00a0.1, or cGVHD (19% W, 28% B, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.1), or primary cause of death. Overall 24\u2010month survival was 61% (95% CI 55%\u201368%) for W, and 60% (95% CI 48\u201375) for B children, log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.7. While HLA matching improved survival in W children, the number of B children receiving HLA\u2010matched HCT was too small to identify the impact of HLA matching on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this contemporary cohort of children with HM, we found that B children were more likely to receive HLA\u2010MMD transplants, but this did not adversely affect survival or GVHD rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29180","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T07:39:24Z","timestamp":1623656364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Race as a factor in donor selection and survival of children with hematologic malignancies undergoing hematopoietic stem cell transplant in Florida"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-5946","authenticated-orcid":false,"given":"Biljana","family":"Horn","sequence":"first","affiliation":[{"name":"University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Lamba","sequence":"additional","affiliation":[{"name":"University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3518-9790","authenticated-orcid":false,"given":"Deepak","family":"Chellapandian","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy for Nonmalignant Conditions, Blood and Marrow Transplant Program, Cancer &amp; Blood Disorders Institute Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri","family":"Sunkersett","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy for Nonmalignant Conditions, Blood and Marrow Transplant Program, Cancer &amp; Blood Disorders Institute Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3548-7720","authenticated-orcid":false,"given":"Jorge Galvez","family":"Silva","sequence":"additional","affiliation":[{"name":"Nicklaus Children's Hospital  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Ziga","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Alperstein","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Joyce","sequence":"additional","affiliation":[{"name":"Nemours Children's Clinic and Wolfson Children's Hospital  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2813-1729","authenticated-orcid":false,"given":"Paul","family":"Castillo","sequence":"additional","affiliation":[{"name":"University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fort","sequence":"additional","affiliation":[{"name":"University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6005-644X","authenticated-orcid":false,"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-2244","authenticated-orcid":false,"given":"Benjamin","family":"Oshrine","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy for Nonmalignant Conditions, Blood and Marrow Transplant Program, Cancer &amp; Blood Disorders Institute Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0395"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.15.2008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-9943-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-778225"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23078"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2004.12.327"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23594"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28367"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_10_13_1","first-page":"825","article-title":"1994 Consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90380-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.214"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25297"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2644"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20628"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2385"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001648"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007535"}],"container-title":["Pediatric Blood &amp; 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