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We describe two cases of acute sickle hepatopathy initiated by primary Epstein\u2013Barr virus (EBV) infection, a previously unreported association. The first case entailed a 14\u2010year\u2010old girl with hemoglobin SC (HbSC) disease who developed hepatic sequestration crisis that responded to a simple transfusion of erythrocytes. The second case was that of a 16\u2010year\u2010old boy with HbSC disease who experienced life\u2010threatening intrahepatic cholestasis with multiorgan failure.<\/jats:p>","DOI":"10.1002\/pbc.29196","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T05:15:10Z","timestamp":1624857310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epstein\u2013Barr virus\u2010induced sickle hepatopathy"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-2618","authenticated-orcid":false,"given":"Alison S.","family":"Towerman","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital  St. Louis Missouri USA"},{"name":"School of Nursing St. Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-7745","authenticated-orcid":false,"given":"David B.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital  St. Louis Missouri USA"},{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis Children's Hospital  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-0046","authenticated-orcid":false,"given":"Monica L.","family":"Hulbert","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091481"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v8.i3.108"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20317"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27060"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80436-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-542076"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31814d6866"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13249"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.72.850.487"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2018.12.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1319972"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000216469.04854.2a"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.02.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200107000-00020"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-6-199803150-00029"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680009300612"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2009.24.4.381"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00739.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2298\/MPNS0604179C"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0835-z"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.881780"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-017-0087-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830130106"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.03.010"}],"container-title":["Pediatric Blood &amp; 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