{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:30Z","timestamp":1788910770973,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The adverse influence of undernutrition in children with cancer may be remediated by early nutritional intervention. This study assessed the efficacy of ready\u2010to\u2010use therapeutic food (RUTF) in improving nutritional status and reducing treatment\u2010related toxicities (TRTs) in such children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized controlled phase\u20103 open\u2010label trial, severely and moderately undernourished children with cancer were randomized 1:1 to receive standard nutritional therapy (SNT) or SNT+RUTF for 6\u00a0weeks. The primary outcome (weight gain &gt;10%) and secondary outcomes (improved\/maintained nutritional status, improved body composition) were assessed after 6\u00a0weeks. TRTs were assessed over 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between July 2015 and March 2018, 260 subjects were enrolled, 126 were analyzable in both arms at 6\u00a0weeks. More children on RUTF had weight gain (98 [77.8%] vs. 81 [64.2%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.025) with a greater increase in fat mass as a percentage of body mass (median 2% [IQR \u22120.12 to 4.9] vs. 0.5% [IQR \u22121.45 to 2.27, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005]) but a greater loss of lean mass (median \u22121.86% [IQR \u22124.4 to 0.50] vs. \u22120.4% [IQR \u22122.4 to 1.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007]) compared to the SNT arm. Fewer subjects on the RUTF arm had episodes of severe infection (10.6% vs. 31%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), treatment delays (17.7% vs. 39%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), and severe mucositis (11% vs. 23.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006) compared to the SNT arm. The odds of developing TRTs on the RUTF arm were lower even after adjusting for improvement in nutritional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RUTF is efficacious in improving weight gain and nutritional status in undernourished children with cancer and decreases TRTs. Incorporating RUTF into a healthy, balanced diet should be considered in undernourished children with cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29197","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T09:20:35Z","timestamp":1625217635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of ready\u2010to\u2010use therapeutic food in malnourished children with cancer: Results of a randomized, open\u2010label phase 3 trial"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-7987","authenticated-orcid":false,"given":"Maya","family":"Prasad","sequence":"first","affiliation":[{"name":"Division of Paediatric Oncology Tata Memorial Centre  Mumbai Maharashtra India"},{"name":"Homi Bhabha National Institute (HBNI)  Mumbai Maharashtra 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