{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:39:30Z","timestamp":1787661570940,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood cancer survivors show a variety of late adverse effects on dental health. The purpose of this study was to examine the prevalence and severity of dental abnormalities in permanent dentition in childhood leukemia survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Retrospective analysis of panoramic radiographs was performed for 178 childhood leukemia survivors aged below 17\u00a0years at the time of diagnosis. Sex, age at diagnosis, interval between ALL diagnosis and the follow\u2010up radiograph, treatment protocol, and risk grouping were recorded. Abnormalities of tooth development and defect index were used to assess the frequency and severity of dental abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eight (61%) patients had no dental abnormalities at follow\u2010up examination at a median of 6.1\u00a0years after diagnosis. Microdontia was more frequent in children under 6\u00a0years of age at the time of diagnosis (5.7% vs. 0.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Significant differences were noted between distinct ALL treatment protocols with more common microdontia in patients treated according to the NOPHO ALL2008 protocol. Tooth agenesis was more frequent in patients that underwent therapy according to high\u2010risk arms compared to intermediate\u2010 or standard\u2010risk arms (3.8% vs. 1.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Patients under 6\u00a0years of age at diagnosis had a significantly higher average defect index score than older patients (7.0 vs. 2.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children and adolescents who received ALL treatment were at risk for dental damage. Young age and high\u2010intensity therapy were associated with the severity of dental abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29200","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:04:30Z","timestamp":1625562270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Late adverse effects of childhood acute lymphoblastic leukemia treatment on developing dentition"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-3509","authenticated-orcid":false,"given":"Egle","family":"Immonen","sequence":"first","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Department of Ear and Oral Diseases Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atte","family":"Nikkil\u00e4","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Tays Cancer Center Tampere University and Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Peltom\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Ear and Oral Diseases Tampere University Hospital  Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Aine","sequence":"additional","affiliation":[{"name":"Department of Ear and Oral Diseases Tampere University Hospital  Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Lohi","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Tays Cancer Center Tampere University and Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_12_2_1","unstructured":"Yleisimpien sy\u00f6pien tapausm\u00e4\u00e4r\u00e4t eri ik\u00e4ryhmiss\u00e4 vuonna 2018. 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