{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:10:05Z","timestamp":1788174605030,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Positron emission tomography (PET)\u2010based measures of baseline total\u2010body tumor burden may improve risk stratification in intermediate\u2010risk Hodgkin lymphoma (HL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Evaluable patients were identified from a cohort treated homogeneously with the same combined modality regimen on the Children's Oncology Group AHOD0031 study. Eligible patients had high\u2010quality baseline PET scans. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were each measured based on 15 thresholds for every patient. Univariate and multivariable Cox regression and Kaplan\u2013Meier survival analyses assessed for an association of MTV and TLG with event\u2010free survival (EFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the AHOD0031 cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a01712), 86 patients were identified who (i) were treated with four cycles of doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide (ABVE\u2010PC) chemotherapy followed by involved field radiotherapy, and (ii) had a baseline PET scan that was amenable to quantitative analysis. Based on univariate Cox regression analysis, six PET\u2010derived parameters were significantly associated with EFS. For each of these, Kaplan\u2013Meier analyses and the log\u2010rank test were used to compare patients with highest tumor burden (i.e., highest 15%) to the remainder of the cohort. EFS was significantly associated with all six PET parameters (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.029). In a multivariable model controlling for important covariates including disease bulk and response to chemotherapy, MTV<jats:sub>2BP<\/jats:sub> was significantly associated with EFS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multiple baseline PET\u2010derived volumetric parameters were associated with EFS. MTV<jats:sub>2BP<\/jats:sub> was highly associated with EFS when controlling for disease bulk and response to chemotherapy. Incorporation of baseline MTV into risk\u2010based treatment algorithms may improve outcomes in intermediate\u2010risk HL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29212","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T12:18:20Z","timestamp":1625919500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prognostic value of baseline metabolic tumor volume in children and adolescents with intermediate\u2010risk Hodgkin lymphoma treated with chemo\u2010radiation therapy: FDG\u2010PET parameter analysis in a subgroup from COG AHOD0031"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-6967","authenticated-orcid":false,"given":"Sarah A.","family":"Milgrom","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Division of Nuclear Medicine, Department of Radiology, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin","family":"Chirindel","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Sciences Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongho","family":"Kim","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Sciences Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Pei","sequence":"additional","affiliation":[{"name":"Children's Oncology Group, Statistics and Data Center, Department of Biostatistics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Children's Oncology Group, Statistics and Data Center, Department of Biostatistics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Buxton","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Statistics and Data Center  Monrovia California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Kessel","sequence":"additional","affiliation":[{"name":"Imaging and Radiation Oncology Core Group  Lincoln Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Leal","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Sciences Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"McCarten","sequence":"additional","affiliation":[{"name":"Imaging and Radiation Oncology Core Group  Lincoln Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-5418","authenticated-orcid":false,"given":"Bradford S.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5234-4134","authenticated-orcid":false,"given":"Suzanne L.","family":"Wolden","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy 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