{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:25:10Z","timestamp":1792121110814,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hodgkin lymphoma (HL) in childhood is an eminently curable disease. Excellent outcomes can be achieved even in resource\u2010limited settings and increasingly, the focus is on limiting long\u2010term toxicity. Contemporary treatment incorporates a risk\u2010stratified, response\u2010adapted approach using multiagent chemotherapy with or without low\u2010dose radiotherapy (RT). Many developing countries continue to use ABVD (adriamycin, bleomycin, vinblastin, and dacarbazine)\u2010based regimen owing to limited acute toxicity, cost, and ease of delivery. We report outcomes of children with early\u2010stage HL using limited cycles of ABVD\u2010based treatment in the first prospective multicentric collaborative study from India InPOG\u2010HL\u201015\u201001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children &lt;18\u00a0years with biopsy\u2010proven HL were enrolled. Patients with stages I and IIA with or without bulky disease were classified as having early\u2010stage disease. Patients were planned to receive four cycles of ABVD subject to satisfactory early response assessment (ERA) scheduled after two cycles of chemotherapy. RT was limited to patients with bulky disease or those with suboptimal ERA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred ten patients were enrolled over 30\u00a0months from 27 centers. One hundred thirty\u2010four were classified as having early\u2010stage disease. Fifty\u2010three (40%) of these had bulky disease. One hundred ten (83%) of this cohort achieved complete or very good partial ERA. Fifty\u2010four (40%) received RT. At a median of 52\u00a0months since diagnosis, 5\u2010year event\u2010free survival (EFS) and overall survival (OS) is 94% and 95.5%, respectively. Treatment\u2010related mortality and abandonment were &lt;1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Limited cycles of ABVD with RT to selected patients is a very effective option for patients with early\u2010stage disease in resource\u2010limited settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29219","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T12:09:46Z","timestamp":1626955786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Treating early\u2010stage Hodgkin lymphoma in resource\u2010limited settings: InPOG\u2010HL\u201015\u201001 experience"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-9468","authenticated-orcid":false,"given":"Amita","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Indraprastha Apollo Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical and Pediatric Oncology Mahavir Cancer Sansthan  Patna India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-4407","authenticated-orcid":false,"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-1403","authenticated-orcid":false,"given":"Sandeep","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Rajiv Gandhi Cancer Institute  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-5816","authenticated-orcid":false,"given":"Venkatraman","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Cancer Institute\u2010Adyar  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-1801","authenticated-orcid":false,"given":"Nishant","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King George's Medical University  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-789X","authenticated-orcid":false,"given":"Rachna","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-4539","authenticated-orcid":false,"given":"Ramandeep Singh","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Max Super Specialty Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Dinand","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Unit BJ Wadia Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Sir Ganga Ram Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2625-7598","authenticated-orcid":false,"given":"Piali","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kalawati Saran 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Report of the Latest Interim Analysis 10th International Symposium on Hodgkin Lymphoma; October 22\u201325 2016; Cologne Germany."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10017"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20157"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318271f587"},{"key":"e_1_2_9_28_1","first-page":"1","article-title":"Can radiotherapy be omitted in children with Hodgkin lymphoma who achieve metabolic remission on interim positron emission tomography? 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