{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:00:41Z","timestamp":1783353641725,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hematopoietic stem cell transplantation (HSCT) is a curative therapy used to treat high\u2010risk hematological malignant disorders and other life\u2010threatening nonmalignant diseases. Gastrointestinal (GI) symptoms post\u2010HSCT might be due to GI graft\u2010versus\u2010host disease (GVHD) or GI infections or both. GI endoscopy with biopsies is safe and beneficial in guiding the management of GI symptoms in children after HSCT, justifying the therapeutic management and contributing to improved outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study including 16 children with malignant and nonmalignant diseases that underwent allogeneic HSCT who had 24 ileo\u2010colonoscopies performed for GI symptoms. To facilitate an evidence\u2010based approach to the endoscopic evaluation of GI symptoms in pediatric patients post HSCT, we examined whether a full ileo\u2010colonoscopy, which includes right colon and terminal ileum (TI), as opposed to a limited sigmoidoscopy, was more accurate in the evaluation of GI symptoms in pediatric patients post HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Specific findings on the right colon\/TI were found in nine out of 24 ileo\u2010colonoscopies (38%, CI\u00a0=\u00a019%\u201359%). The macroscopic findings on ileo\u2010colonoscopy were compared with the histopathologic findings. When macroscopic findings were present, there were matching histopathologic findings in 100% of cases. However, even in the absence of any macroscopic findings on ileo\u2010colonoscopy, there were histopathological findings in 29% of the cases (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This cohort favors ileo\u2010colonoscopy over sigmoidoscopy, with systematic biopsy sampling, in evaluating GI symptoms in pediatric patients post HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29235","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T13:24:57Z","timestamp":1626355497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of gastrointestinal symptoms in pediatric patients post hematopoietic stem cell transplantation: Ileo\u2010colonoscopy versus sigmoidoscopy. A single\u2010center experience and review of literature"],"prefix":"10.1002","volume":"68","author":[{"given":"Mordechai","family":"Slae","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-7274","authenticated-orcid":false,"given":"Diana","family":"Pinhasov","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Averbuch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev","family":"Davidovics","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-6376","authenticated-orcid":false,"given":"Ehud Even","family":"Or","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant and Cancer Immunotherapy Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Reif","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Stepensky","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant and Cancer Immunotherapy Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-0935","authenticated-orcid":false,"given":"Irina","family":"Zaidman","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant and Cancer Immunotherapy Hadassah \u2010 Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12723"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000570"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.08.040"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2016.19.1.29"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20924"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12604"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.137"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001776"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.031"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0829-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.126"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705453"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.07.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200627"}],"container-title":["Pediatric Blood &amp; 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