{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:18:40Z","timestamp":1779340720399,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010anaplasticperipheral T\u2010cell lymphomas (PTCL) are rare tumors in children, adolescents, and young adults (CAYA) with poor prognosis and scarce genetic data. We analyzed lymphoma tissue from 36 patients up to 18\u00a0years old with PTCL, not otherwise specified (PTCL\u2010NOS), hepatosplenic T\u2010cell lymphoma, Epstein\u2013Barr virus (EBV)\u2010positive T\u2010lymphoproliferative diseases, subcutaneous panniculitis\u2010like T\u2010cell lymphoma, and other PTCL types. Twenty\u2010three patients (64%) had at least one genetic variant detectable, including <jats:italic>TET2<\/jats:italic>, <jats:italic>KMT2C<\/jats:italic>, <jats:italic>PIK3D<\/jats:italic>, and <jats:italic>DMNT3A<\/jats:italic>. <jats:italic>TP53<\/jats:italic> and <jats:italic>RHOA<\/jats:italic> variants, commonly found in adults, were not identified. Eight of 20 (40%) CAYA PTCL\u2010NOS had no detectable mutations. The genetic findings suggest that CAYA PTCL differ from adult cases.<\/jats:p>","DOI":"10.1002\/pbc.29285","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:18:24Z","timestamp":1628839104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular features of non\u2010anaplastic peripheral T\u2010cell lymphoma in children and adolescents"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3137-0886","authenticated-orcid":false,"given":"Rex K. H.","family":"Au\u2010Yeung","sequence":"first","affiliation":[{"name":"Department of Pathology, Hematopathology Section and Lymph Node Registry University of Kiel\/University Hospital Schleswig\u2010Holstein  Kiel Germany"},{"name":"Department of Pathology, Queen Mary Hospital The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section and Lymph Node Registry University of Kiel\/University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-993X","authenticated-orcid":false,"given":"Ingram","family":"Iaccarino","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section and Lymph Node Registry University of Kiel\/University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy","family":"Abramov","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-2812","authenticated-orcid":false,"given":"Chris M.","family":"Bacon","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust and Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-3675","authenticated-orcid":false,"given":"Olga","family":"Balagu\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Clinic, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS) University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2229-5973","authenticated-orcid":false,"given":"Emanuele S. 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