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We present the case of a 16\u2010year\u2010old male patient with Ph+ ALL who underwent matched sibling donor HCT and developed autoimmune\u2010like hepatitis after receiving ponatinib for post\u2010HCT maintenance, evidenced by marked plasma cell infiltrate on liver biopsy. He was successfully treated with steroids and daratumumab, an anti\u2010CD38\u2010monoclonal antibody. The dramatic response in this patient warrants expanded investigation of daratumumab for plasma cell\u2010mediated disorders post\u2010HCT. It further highlights that identifying mechanisms of immune\u2010mediated injury can allow for directed therapy and limit exposure to broad immune suppression.<\/jats:p>","DOI":"10.1002\/pbc.29290","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:23:10Z","timestamp":1628839390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting plasma cells with daratumumab aids in the treatment of post\u2010transplant autoimmune\u2010like hepatitis"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-0732","authenticated-orcid":false,"given":"Rebecca","family":"Epperly","sequence":"first","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis 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