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Currently, in North America, only the BNT162b2 (Pfizer\u2010BioNTech<jats:styled-content>)<\/jats:styled-content> mRNA vaccine is approved for individuals aged 12\u201317. Most patients treated with contemporary regimens for acute lymphoblastic leukemia receive PEG\u2010asparaginase (PEG\u2010ASNase) and 10%\u201330% will develop allergic reactions. Optimizing access and safety for vaccine administration for these patients is critical. This report describes a process developed to support COVID vaccination in a cohort of adolescents and young adults with a history of PEG\u2010ASNase allergy.<\/jats:p>","DOI":"10.1002\/pbc.29295","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T14:28:45Z","timestamp":1629124125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Safety of administration of BNT162b2 mRNA (Pfizer\u2010BioNTech) COVID\u201019 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG\u2010asparaginase"],"prefix":"10.1002","volume":"68","author":[{"given":"Catherine","family":"Mark","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-3670","authenticated-orcid":false,"given":"Sumit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-0823","authenticated-orcid":false,"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Upton","sequence":"additional","affiliation":[{"name":"Division of Immunology\/Allergy The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Orkin","sequence":"additional","affiliation":[{"name":"Paediatric Medicine Division The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelle","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Division of Immunology\/Allergy The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Clarke","sequence":"additional","affiliation":[{"name":"Corporate Strategy &amp; Performance The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Heisey","sequence":"additional","affiliation":[{"name":"Department of Surgery The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"McGovern","sequence":"additional","affiliation":[{"name":"Department of Surgery The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-1702","authenticated-orcid":false,"given":"Sarah","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) pandemic.World Health Organization. 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