{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:49:26Z","timestamp":1770749366747,"version":"3.50.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use of whole\u2010brain radiotherapy (WBRT) versus focal radiotherapy, including stereotactic radiosurgery or stereotactic radiotherapy, for these indications are limited. We report a single institution experience of 26 pediatric patients treated with radiotherapy for solid tumor CNS metastases without leptomeningeal disease. Focal radiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) was well tolerated and survival outcomes did not differ between patients treated with WBRT (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) versus focal radiation, suggesting that focal radiotherapy may be considered for patients with limited CNS metastases.<\/jats:p>","DOI":"10.1002\/pbc.29331","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T16:48:37Z","timestamp":1632761317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcomes for pediatric patients receiving radiotherapy for solid tumor central nervous system metastases"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-2831","authenticated-orcid":false,"given":"Thomas P.","family":"Howard","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Brigham and Women's Hospital, Boston 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