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One hundred twenty\u2010eight Ewing sarcoma patients were enrolled and 124 events occurred. The 6\u2010month EFS was 12.7%, demonstrating the poor outcome of these patients. Only docetaxel achieved its protocol\u2010specified radiographic response rate for activity; however, the EFS for docetaxel was similar to other agents, indicating that a higher radiographic response rate may not translate into superior disease control. This EFS benchmark could be utilized as an additional endpoint in trials for recurrent Ewing sarcoma.<\/jats:p>","DOI":"10.1002\/pbc.29333","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T14:51:01Z","timestamp":1631112661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Outcome of patients with relapsed or progressive Ewing sarcoma enrolled on cooperative group phase 2 clinical trials: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-7826","authenticated-orcid":false,"suffix":"III","given":"Anderson B.","family":"Collier","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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DuBoisS GrierHE et\u00a0al.A phase III randomized trial of adding voncristine\u2010topotecan\u2010cyclophosphamide (VTC) to standard chemotherapy in initial treatment of non\u2010metastatic Ewing sarcoma\u2013a report from the Children's Oncology Group. Paper presented at: 2019 CTOS Annual Meeting;2019;Tokyo Japan."},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","unstructured":"WheatleyKK KhanM FenwickN et\u00a0al.Correlation of response with progression\u2010free (PFS) and overall (OS) survival in relapsed\/refractory Ewing sarcoma (RR\u2010ES): results from the rEECur trial. 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