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The <jats:italic>KMT2A\u2010MAML2<\/jats:italic> transcript was expressed at low level. The patient was prospectively followed. The inv(11) was undetectable in ensuing samples. Leukemia never developed after a 12.8\u2010year follow\u2010up period. Enriched etoposide\u2010induced TOP2A cleavage in the relevant <jats:italic>MAML2<\/jats:italic> genomic region supports a TOP2A DNA damage mechanism. After completing TOP2 poison chemotherapies, covert <jats:italic>KMT2A<\/jats:italic>\u2010R clones may occur in a small minority of patients; however, not all <jats:italic>KMT2A<\/jats:italic> rearrangements herald a therapy\u2010related leukemia diagnosis.<\/jats:p>","DOI":"10.1002\/pbc.29344","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T13:45:10Z","timestamp":1632318310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>KMT2A\u2010MAML2<\/i> rearrangement emerged and regressed during neuroblastoma therapy without leukemia after 12.8\u2010year follow\u2010up"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4335-6993","authenticated-orcid":false,"given":"Carolyn A.","family":"Felix","sequence":"first","affiliation":[{"name":"Division of Oncology, The Children's Hospital of Philadelphia Center for Childhood Cancer Research  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