{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:18:07Z","timestamp":1770887887005,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The SIOPEL\u20104 study has demonstrated that dose\u2010dense cisplatin\u2010based chemotherapy dramatically improves outcome in children with high\u2010risk hepatoblastoma in western countries. However, the feasibility and safety of this regimen have not been clarified in Japanese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pilot study, JPLT3\u2010H, was designed to evaluate the safety profile of the SIOPEL\u20104 regimen in Japanese children with newly diagnosed hepatoblastoma with either metastatic disease or low alpha\u2010fetoprotein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 patients (three female) were enrolled. Median age was 2 years (range, 0\u201314). Three patients were PRETEXT II (where PRETEXT is PRETreatment EXTent of disease), six PRETEXT III, and six PRETEXT IV. All patients had lung metastasis, none had low alpha\u2010fetoprotein. Eight patients completed the prescribed treatment, and seven patients discontinued therapy prematurely, four due to progressive disease and three due to causes other than severe toxicity. Grade 4 neutropenia was documented in most patients in preoperative cycles A1\u20103 (11\/15 in A1, 9\/11 in A2, and 7\/11 in A3) and in all considering all cycles. Grade 3\u20134 thrombocytopenia and grade 3 anemia were also frequently observed. Patients experienced several episodes of grade 3 febrile neutropenia, but none had grade 4 febrile neutropenia or severe infections. One patient had grade 3 heart failure only in the first cycle. Other grade 3 or 4 toxicities were hypomagnesemia, anorexia, nausea, mucositis, liver enzyme elevation, fever, infection, and fatigue. There were no unexpected severe toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The toxicity profile of JPLT3\u2010H was comparable to that of SIOPEL\u20104. Dose\u2010dense cisplatin\u2010based chemotherapy may be feasible among Japanese patients with high\u2010risk hepatoblastoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29389","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T10:30:55Z","timestamp":1633516255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Feasibility of dose\u2010dense cisplatin\u2010based chemotherapy in Japanese children with high\u2010risk hepatoblastoma: Analysis of the JPLT3\u2010H pilot study"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-3082","authenticated-orcid":false,"given":"Kenichiro","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Shizuoka Children's Hospital  Shizuoka 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