{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:26:34Z","timestamp":1775582794937,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to estimate the frequency of hearing screening failures in pediatric cancer survivors at low risk for hearing loss and evaluate the feasibility of administering screenings in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Survivors in the St. Louis Children's Hospital Late Effects Clinic were recruited. Eligibility included (a) diagnosis of a pediatric cancer treated without platinum chemotherapy or cranial radiation, (b) at least 6\u00a0months from completion of therapy, (c) between the ages of 7 and 18\u00a0years, (d) cognitively\/behaviorally able to participate, and (e) English speaking. Behavioral hearing screenings from 1000 to 8000\u00a0Hz were performed by trained personnel using a calibrated audiometer. A failed screen was defined by a participant not responding to two or more of the three screening attempts for at least one frequency in at least one ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred nine patients met eligibility criteria with 78 enrolled (71.5%). Diagnoses included leukemia (57.7%), sarcoma (11.5%), Wilms tumor (14.1%), lymphoma (12.8%), and other solid tumors (3.9%). The median age was 13.2\u00a0years (Q1\u2013Q3: 9.6\u201315.4) and the median time from treatment completion was 3.7\u00a0years (Q1\u2013Q3: 2.3\u20137.4). Eighteen patients (23%) failed the hearing screen (95% CI: 14%\u201334%). No demographic or treatment\u2010related variables were significantly correlated to screening failure. Six screen failures (33%) underwent formal audiology assessments, with three demonstrating unilateral hearing loss: two conductive and one sensorineural.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant fraction of pediatric cancer survivors at low risk for hearing loss failed hearing screening. Broader use of hearing screening should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29437","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T10:21:38Z","timestamp":1638440498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of hearing screening failures in low\u2010risk childhood cancer survivors"],"prefix":"10.1002","volume":"69","author":[{"given":"Meghan","family":"Phelan","sequence":"first","affiliation":[{"name":"Program in Audiology and Communication Sciences Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan S.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Audiology St. Louis Children's Hospital  St. Louis Missouri 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