{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:34:11Z","timestamp":1787506451959,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Outcome of children with bladder\u2013prostate rhabdomyosarcoma (RMS) has improved with multimodal therapies, including surgery and\/or radiotherapy for local treatment. Our aim was to report long\u2010term urological complications after a conservative approach combining conservative surgery and brachytherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Eighty\u2010six patients, free of disease, were retrospectively reviewed. Symptoms related to urinary tract obstruction, incontinence, infection, and lithiasis were reported and graded according to the Common Terminology Criteria for Adverse Events (CTCAE) classification. Only symptomatic patients underwent urodynamic studies. Risk factors for complications were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 76 males and 10 females. The median follow\u2010up was 6.3\u00a0years (18\u00a0months to 24\u00a0years). Complications occurred after a median follow\u2010up of 5\u00a0years (0\u201321). Twenty\u2010two patients (26%) had long\u2010term urological complications. Urinary tract obstruction was found in 15 patients (17%) and urinary incontinence in 14 patients (16%). Recurrent urinary tract infection occurred in four patients and urinary lithiasis in four (5%). The underlying physiopathology included bladder dysfunction in 15 patients (17%), urethral stenosis in six (7%), and ureterovesical junction stenosis in five (6%). On univariate analysis, posterior bladder wall dissection (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001), bladder neck trigone dissection (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.010), and partial prostatectomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.023) were significantly associated with an increased risk of bladder dysfunction; on multivariate analysis, only age \u22642\u00a0years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.028) at operation and posterior bladder wall dissection (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006) were found to be significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The conservative surgical approach combined with brachytherapy for bladder\u2013prostate RMS leads to long\u2010term urological complications in 26% of survivors. Optimizing brachytherapy doses for young children and establishing a clear and long\u2010term follow\u2010up protocol could help to reduce these complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.29532","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T07:56:25Z","timestamp":1641455785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term urological complications after conservative local treatment (surgery and brachytherapy) in children with bladder\u2013prostate rhabdomyosarcoma: A single\u2010team experience"],"prefix":"10.1002","volume":"69","author":[{"given":"Rezkalla","family":"Akkary","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Bic\u00eatre Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris Paris\u2010Saclay University  Le Kremlin\u2010Bic\u00eatre 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Pediatric Surgery, Armand Trousseau Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-9994","authenticated-orcid":false,"given":"Luca","family":"Pio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Bic\u00eatre Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris Paris\u2010Saclay University  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-5207","authenticated-orcid":false,"given":"Veronique","family":"Minard\u2010Colin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gustave Roussy Cancer Campus  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Haie\u2010Meder","sequence":"additional","affiliation":[{"name":"Brachytherapy Unit, Department of 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