{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:15:56Z","timestamp":1790601356883,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Approximately 7%\u201350% of children with medulloblastoma (MB) develop postoperative cerebellar mutism syndrome (pCMS). pCMS has a short\u2010term negative impact on intelligence, but effects on long\u2010term outcomes are contradictory. The aim of this study was to assess long\u2010term effects of pCMS in MB patients on aspects of intelligence quotient (IQ) and its perioperative risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center retrospective cohort study, 31 children were included (14 pCMS). Perioperative risk factors included brainstem invasion, vermis incision, hydrocephalus, tumor size, severity of pCMS, neurological symptoms, mean body temperature (BT) on days 1\u20134 post surgery, and age at resection. Age\u2010appropriate Wechsler Intelligence tests were assessed at least 2\u00a0years after tumor resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean interval between tumor resection and neuropsychological evaluation was 3.9\u00a0years in pCMS and 4\u00a0years and 11\u00a0months in the no\u2010pCMS group. No significant differences in IQ scores were found between groups. The pCMS group had a clinically relevant difference of 10 points when compared to age norms on verbal IQ (VIQ). Bilateral pyramidal and swallowing problems were risk factors for lower performance. In the overall group, tumor size, younger age at surgery, and raised mean BT were negatively correlated with aspects of IQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found a clinically significant reduction of VIQ in the pCMS patient group. pCMS patients with a larger tumor size, younger age at surgery, a higher mean BT in the first days after surgery, bilateral pyramidal symptoms, and swallowing problems 10\u00a0days post surgery are more at risk for VIQ deficits at long\u2010term.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29536","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T11:24:16Z","timestamp":1640949856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Perioperative risk factors for long\u2010term intelligence in children with postoperative cerebellar mutism syndrome after medulloblastoma surgery"],"prefix":"10.1002","volume":"69","author":[{"given":"Femke K.","family":"Aarsen","sequence":"first","affiliation":[{"name":"Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Lise C.","family":"van Veelen\u2010Vincent","sequence":"additional","affiliation":[{"name":"Paediatric Neurosurgery Erasmus MC\/Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Partanen","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coriene E.","family":"Catsman\u2010Berrevoets","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology, Erasmus MC\/Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Paediatric Neurosurgery, Erasmus MC\/Sophia Children's Hospital  Rotterdam The 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