{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:08:57Z","timestamp":1789765737862,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myocardial iron deposition is a significant cause of morbidity and mortality in patients with transfusion\u2010dependent thalassemia (TDT). Amlodipine, L\u2010type calcium channel blocker with regular chelation therapy may reduce myocardial iron overload. Lack of randomized trials prompted this study to assess the effect of calcium channel blocker (amlodipine) in combination with iron chelation therapy on iron overload in patients with TDT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010four eligible patients were randomized to receive either amlodipine and chelation (group A) or chelation alone (group B) in double\u2010blind placebo\u2010controlled trial. Myocardial iron concentration (MIC) using T2* magnetic resonance imaging (MRI), liver iron concentration (LIC), left ventricular ejection fraction (LVEF), and serum ferritin were measured at baseline and 12\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the amlodipine group, mean cardiac T2* value significantly increased from 18.11 \u00b1 8.47 to 22.15 \u00b1 7.61 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002) at 12\u00a0months, whereas in control group, there was a nonsignificant increase (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.62) in cardiac T2* value from 19.50 \u00b1 8.84 to 20.03 \u00b1 9.07. There was a significant decrease in MRI\u2010derived MIC in the amlodipine group compared to control group (1.93 \u00b1 1.61 to 1.29 \u00b1 0.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). Changes in the LVEF (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.45), MRI\u2010derived LIC (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.09), and serum ferritin (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.81) were not significant between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Amlodipine is safe and when combined with chelation therapy appears to be more effective in reducing cardiac iron overload than chelation only in children and young adults with TDT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.29564","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T07:57:56Z","timestamp":1643443076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of the effects of calcium channel blockers plus iron chelation therapy versus chelation therapy only on iron overload in children and young adults with transfusion\u2010dependent thalassemia: A randomized double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-7533","authenticated-orcid":false,"given":"Vineeta","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhesh","family":"Raj","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1536","article-title":"The burden of hemoglobinopathies in India and the challenges ahead","volume":"10","author":"Balgir RS","year":"2000","journal-title":"Curr Sci"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.29"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-586677"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01782.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085517"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.05.002"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"21","article-title":"Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children","volume":"41","author":"Gomber S","year":"2004","journal-title":"Indian Pediatr"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-016-0821-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15436-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243799"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12507"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000525"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-721183"},{"issue":"7","key":"e_1_2_11_15_1","article-title":"Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion dependent beta thalassemia","volume":"7","author":"Sadaf A","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13083"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S211630"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12977"}],"container-title":["Pediatric Blood &amp; 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