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We sought to measure willingness to participate by focusing on sickle cell disease (SCD), in which approximately 90% of affected individuals are Black. We conducted an analysis of 17 RCTs. A level of clarity was defined and correlated with each article's transparency in reporting patient enrollment data. Calculated measures of acceptance ranged from 32% to 93.5%. Calculated completion rates ranged from 58.8% to 100%. Weighted measures of acceptance and completion were 59.1% and 83.8%, respectively. Our study is limited by focusing solely on studies pertinent to SCD and only a minority of publications reviewed provided sufficient patient enrollment data. Yet, our results suggest that decreased willingness to participate does not account for underrepresentation of Black individuals.<\/jats:p>","DOI":"10.1002\/pbc.29580","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T11:06:15Z","timestamp":1645441575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Black Americans\u2019 willingness to participate in pediatric sickle cell clinical trials: A retrospective, systematic review"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-0016","authenticated-orcid":false,"given":"Sara","family":"Zanfardino","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology at Akron Children's Hospital  Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volha","family":"Mazziotto","sequence":"additional","affiliation":[{"name":"Department of Hematology and 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