{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:26:29Z","timestamp":1777134389019,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neuropathic pain (NP) has been previously explored in adolescents with sickle cell disease (SCD). This study aims to describe the prevalence of NP in adolescents with SCD at a single institution and to explore associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We used the painDETECT questionnaire, one of the few pain phenotyping questionnaires validated for adolescents. We also evaluated the relationships between painDETECT scores and frequency of acute care visits and admissions for pain in the previous 12\u00a0months, and age, respectively. Patients 12\u201318\u00a0years old were surveyed from June to July 2019. A retrospective approach was used to answer the remaining research questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one and seven surveys were completed in the outpatient and inpatient settings, respectively. PainDETECT scores suggestive of NP were more prevalent in inpatient surveys than in outpatient surveys. The difference between the mean painDETECT scores of each group was significant when using a general linear mixed model. Most inpatients surveyed had \u22653 pain events in the previous 12\u00a0months. Further, older age and increased number of pain events in the previous 12\u00a0months were independently associated with higher painDETECT scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, in our opinion, NP is not being evaluated for and treated sufficiently in pediatric SCD, especially in the setting of inpatient acute vaso\u2010occlusive crisis. Age and number of acute pain events\/admissions in the previous 12\u00a0months can be used to identify patients likely to be at risk for NP. It is important to continue to identify NP and develop NP\u2010targeting treatment plans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29583","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:34:47Z","timestamp":1644582887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence of neuropathic pain in adolescents with sickle cell disease: A single\u2010center experience"],"prefix":"10.1002","volume":"69","author":[{"given":"Melissa","family":"Cregan","sequence":"first","affiliation":[{"name":"Department of Biostatistics Department of Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Hematology Ohio University Heritage College of Osteopathic Medicine  Athens Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latika","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Hematology Loma Linda University  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Department of Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-2744","authenticated-orcid":false,"given":"Doralina","family":"Anghelescu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Department of Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201004\u2010383430"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21408"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28698"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2020.03.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24838"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25574"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774516636573"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)30471-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23575"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010019\u20101082\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134445"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000265"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000142"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010020\u201000885\u20105"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012943.pub2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.534"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X132488"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.07.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199611000-00002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010017\u20102984\u2010z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8020084"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945919836446"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000143"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000765"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010017\u20100263\u2010z"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102327"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463720920682"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001407"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102016\u2010218614"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000214"}],"container-title":["Pediatric Blood &amp; 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