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Lymphedema can be isolated or associated with genetic syndromes, thus it is very important to identify the correct diagnosis, to select carefully which patients to refer for genetic testing, and to initiate appropriate treatment in a timely fashion. In this article, we review key information about diagnosis of lymphedema, associated conditions and syndromes, and current treatment modalities.<\/jats:p>","DOI":"10.1002\/pbc.29611","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T14:11:23Z","timestamp":1649686283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How we approach lymphedema in the pediatric population"],"prefix":"10.1002","volume":"69","author":[{"given":"Irina","family":"Pateva","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology, Rainbow Babies and Children's Hospital, Cleveland Medical Center Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arin K.","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Plastic and Oral Surgery, Lymphedema Program Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-0162","authenticated-orcid":false,"given":"Kristen M.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Comprehensive Vascular Anomalies Program, Solid Tumor Program, Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2003.05.17.35.45.c3392"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/804675"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31820a64f3"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg126"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269216305pm1020oa"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318213a218"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00309-7"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-6-552"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182365c91"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0032"},{"issue":"2","key":"e_1_2_14_12_1","first-page":"206","article-title":"Primary lymphedema in children and adolescents: a follow\u2010up study and review","volume":"76","author":"Smeltzer DM","year":"1985","journal-title":"Pediatrics"},{"issue":"6","key":"e_1_2_14_13_1","first-page":"541","article-title":"Diagnosis and treatment of primary lymphedema. 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