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Treatment options are limited, given their tendency to regrow following surgery and their propensity to transform into malignant tumours following radiation. Selumetinib is an oral selective inhibitor of RAS\u2010mitogen\u2010activated protein kinase (MAPK) 1 and 2, which has shown efficacy for tumour shrinkage\/stabilisation and symptom improvement. We report a national case series of 19 children treated with selumetinib. All patients experienced symptom improvement or stabilisation with an acceptable toxicity profile, including those patients previously treated with trametinib. This real\u2010world experience confirms previous trials showing significant clinical benefit for this patient population.<\/jats:p>","DOI":"10.1002\/pbc.29633","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T06:46:30Z","timestamp":1647326790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Selumetinib for symptomatic, inoperable plexiform neurofibromas in children with neurofibromatosis type 1: A national real\u2010world case series"],"prefix":"10.1002","volume":"69","author":[{"given":"Hallie","family":"Coltin","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Programme in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre Hospital for Sick Children  Toronto Ontario 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