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After two and three doses of bevacizumab, respectively, the levels dropped dramatically to 191 and 178\u00a0mg\/dl, respectively. Bevacizumab treatment was associated with a decrease in CSF protein level, allowing successful shunt placement. Our results are consistent with the pharmacological mechanism of bevacizumab, which decreases protein leakage from blood vessels to the ventricles.<\/jats:p>","DOI":"10.1002\/pbc.29637","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T09:20:47Z","timestamp":1646212847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduction in the cerebrospinal fluid protein level after bevacizumab treatment in patients with optic pathway low\u2010grade gliomas"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3552-6347","authenticated-orcid":false,"given":"Marcos Devanir","family":"da Costa","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Universidade Federal de Sao Paulo  Sao Paulo Sao Paulo Brazil"},{"name":"Division of Neurosurgery Instituto de Oncologia Pediatrica (IOP\/GRAACC)  Sao Paulo Sao Paulo 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